GRS 2017
Permanent URI for this collectionhttps://hdl.handle.net/10657/2210
This collection gathers posters, talks, and performances presented at the 2017 Graduate Research and Scholarship Projects Day.
Browse
Browsing GRS 2017 by Department "Biology and Biochemistry, Department of"
Now showing 1 - 7 of 7
- Results Per Page
- Sort Options
Item A Proteomic Signature of Dormancy in an Actinobacterium: Micrococcus luteus(2017) Mali, Sujina; Rangel, Jonathan; Mitchell, Morgan; Havis, Spencer; Bodunrin, Abiodun; Khan, Arshad; Widger, William R.; Bark, Steven J.This project was completed with contributions from Arshad Khan from the Department of Pathology and Laboratory Medicine, UT Health Science Center, Houston.Item Cannabis Terpenes Synergistically Modulate Hippocampal Excitability(2017) Abdulla, Ahmad; Hosseini-Zareh, Mahshid; Ziburkus, JokubasThis work demonstrates how commonly ingested aromatic compounds (terpenes, flavonoids, and odorants) can induce physiological changes on the molecular level in brain regions implicated in high order information processing. Indeed, the component discussed in this study (BCP) is found in relatively high concentrations in common household spices such as cloves and black pepper. Also, limonene is commonly found in the rinds of citrus fruits (e.g. lemon and oranges). These physiological actions could be responsible for individual preferences of different types of foods and aromas that act synergistically with our bodies and modify behavior. Lastly, the need for effective treatments for severe pharmacoresistant forms of pediatric epilepsies such as Dravet syndrome is of imminent importance. Due to current drug laws, it is legally and financially impractical for many people to obtain high quality and high concentration C. sativa extracts. This could lead to ingestion of inferior products with chemical contamination or highly variable concentrations of chemical components. This issue may be completely circumvented by using natural non-cannabis derived cannabinoid agonists. The only limitation is our lack of knowledge and testing regarding these substances.Item Characterization of the Pro-Survival Role of Kinase-Independent EGFR in Cancer(2017) Srivastava, Shivangi; Katreddy, Rajashekara; Thomas, Rintu; Zhang, WeihuaEGFR (Epidermal Growth Factor Receptor), a receptor tyrosine kinase is overexpressed or mutated in a variety of tumors of epithelial origin. Although, its kinase activity is well characterized and is being targeted in the clinic, still patients develop resistance and stop responding to TKIs. Therefore, there is a need to understand the kinase-independent functions of EGFR and how it can be clinically targeted. Here, I describe the work that tests the hypothesis that EGFR independent of its tyrosine kinase activity mediates survival of cancer cells under various physiological stresses and thereby promoting resistance against TKIs.Item Developing the Zebrafish Neuromast Assay as a Predictive Toxicity Model(2017) Mirchandani, Rachna; Thrikawala, Savini; Stephan, Cliff; Nguyen, Nghi; Sobieski, Mary; Judson, Richard S.; Gustafsson, Jan-Åke; Bondesson, MariaWe developed a method for rapid screening of large number of chemicals to identify zebrafish neuromast disruptors. We identified serotonin as a possible pathway being targeted by the disruptors which we confirmed through some preliminary experiments. This project was completed with contributions from Cliff Stephan, Nghil Nguyen, and Mary Sobieski from the Center for Translational Cancer Research, IBT; Richard S. Judson from the National Center for Computational Toxicology, US EPA; and Maria Bondesson from Intelligent Systems Engineering, Indiana University.Item Effects of Pyriproxyfen Exposure on Nervous System Develpment in Zebrafish(2017) Thrikawala, Savini; Gustafsson, Jan-Åke; Bondesson, MariaPyriproxyfen is used in agricultural and veterinary pests. It is also used to treat drinking water sources, to prevent mosquito breeding. Therefore, it is debated that pyriproxyfen treated water consumption can cause microcephaly in newborns. We aimed to study the effect of pyriproxyfen on nervous system development, and whether it can cause brain effects. This project was completed with contributions from Maria Bondesson from Intelligent Systems Engineering, Indiana University.Item Satellite Repeats Are Associated with Host Tolerance of an Active TE(2017) Lama, Jyoti; Kelleher, Erin S.Item The Evolutionary Causes and Consequences of Successful Asexuality in Tetrahymena ciliate(2017) Zhang, Hao; West, Joe; Zufall, Rebecca A.; Azevedo, Ricardo B. R.