Developing the Zebrafish Neuromast Assay as a Predictive Toxicity Model

We developed a method for rapid screening of large number of chemicals to identify zebrafish neuromast disruptors. We identified serotonin as a possible pathway being targeted by the disruptors which we confirmed through some preliminary experiments. This project was completed with contributions from Cliff Stephan, Nghil Nguyen, and Mary Sobieski from the Center for Translational Cancer Research, IBT; Richard S. Judson from the National Center for Computational Toxicology, US EPA; and Maria Bondesson from Intelligent Systems Engineering, Indiana University.