GRS 2017
Permanent URI for this collectionhttps://hdl.handle.net/10657/2210
This collection gathers posters, talks, and performances presented at the 2017 Graduate Research and Scholarship Projects Day.
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Item 3D Modeling of Chromosomes Territories in Normal and Aneuploid Nuclei(2017) Yen, Fan-Yun; Merchant, Fatima AzizItem A Library in C++ for Graphical Password and Human Verification(2017) Limaye, Sagar; Biyani, Pulkit; Moghe, VaibhaviA graphical authentication method is implemented through selection of discretized points on an image. Discretization is used in click-based graphical passwords so that approximately correct entries can be accepted by the system. For human verification, we make use of a grid of images where users are asked to select certain images matching a common feature or description, as an alternative against text-based verification. This is a library of a security system, which provides an API for authentication and human verification.Item A New Robot-Assisted Therapy for Stroke Survivors: Effects of Long-Term Stretching Exercises on Ankle Range of Motion, Balance and Gait(2017) Yoo, Dongyual; Lee, Beom-Chan; Son, YounsunOur study has demonstrated that stroke survivors received ankle stretching exercises with the MAS for 4 weeks improved ankle range of motion, balance, and gait ability. These improvements remained relatively constant through the retention period (i.e., 1 month after the completion of the exercises). The findings have two important clinical implications: 1) stroke survivors could use the MAS in clinical or home environments, and 2) physical therapists could prescribe or adapt the MAS exercise sessions as needed.Item A Novel Demand Response Management Model to Reduce Smart Grid Costs(2017) Ahmadian, Saeed; Malki, Heidar A.; Barati, MasoudDRM means leveling demand curve based on electricity prices. Indeed, using variable price rates, electricity consumers are encouraged to use electricity in periods with cheap electricity price ranges. Therefore, total system cost would decrease efficiently. Motivations: To model dynamics between electricity end-users and utility companies. To present a model with simple implementation on smart households. To reduce electricity production costs and to maximize social welfare.Item A Potential New Treatment Paradigm for Multiple Sclerosis(2017) Nikhar, Sameer; Degterev, Alexei; Cuny, Gregory D.This project was completed with contributions from Alexei Degterev from the Department of Developmental, Molecular and Chemical Biology, School of Medicine, Tufts University, Boston.Item A Proteomic Signature of Dormancy in an Actinobacterium: Micrococcus luteus(2017) Mali, Sujina; Rangel, Jonathan; Mitchell, Morgan; Havis, Spencer; Bodunrin, Abiodun; Khan, Arshad; Widger, William R.; Bark, Steven J.This project was completed with contributions from Arshad Khan from the Department of Pathology and Laboratory Medicine, UT Health Science Center, Houston.Item A Study of the Effects of Image Congruence on Customers' Brand Loyalty in Luxury Hotels(2017) Li, Xiao (Lilac); Back, Ki-JoonThis study constructs a new model for investigating the relationship between image congruence and brand personality, challenges the existing research model in this field, and offers fresh insight into brand research. And, this study points out a multi-dimensional perspective to explore the effect of image congruence. This study aims to conduct the model to focus on constructing the brand loyalty for Aman, which possess the distinctive brand personality. At the same time, this study aims to develop a model which can be broadly apply to managers in the luxury hospitality industries.Item Achieving Higher Quality Healthcare at Lower Costs: Efficacy and Unintended Consequences of Accountable Care Organization(2017) Nwafor, Onyi; Johnson, Norman A.Accountable Care Organizations (ACOs) are groups of healthcare organizations that agree to assume joint responsibility for the quality and costs of care for a defined patient population. - 1,000 (or 20%) of US hospitals participating. - 28 million beneficiaries. - Expected to reach 105 million persons in 2020. - Start-up and operating costs: $11.6 million - $26.1 million.Item Adherence Barriers to Oral Endocrine Therapy Among Breast Cancer Patients(2017) Paranjpe, Rutugandha; Abughosh, Susan M.Breast cancer is the most common type of cancer among women and the 2nd most prevalent cause of cancer deaths in women in the United States. Approximately 70-80% of all breast cancer express hormone receptors (HR) and are called HR-positive (HR+) breast cancer. For HR+ breast cancer, the standard systematic therapy is endocrine therapy (ET) which include selective estrogen receptor modulators like Tamoxifen, and aromatase inhibitors to inhibit the estrogen synthesis. For patients diagnosed with early-stage HR+ breast cancer, ET reduces breast cancer recurrence, metastasis, and mortality. The clinical benefit of ET is maximized when ET is taken daily for 5-10 years. Despite the well-documented clinical benefit of ET, nearly 50% of breast cancer survivors taking ET are non-adherent and 70% discontinue therapy before the recommended 5year. Low adherence and early discontinuation are associated with an increased risk of mortality, enhanced medical costs and lower quality of life years. The determinants of non-adherence and non-persistence are multi-dimensional and should be considered when designing interventions to enhance adherence.Item An Efficient Hair Removal Algorithm for Skin Lesion Images(2017) Pan, Rangeet; Zouridakis, GeorgeItem An Integrated Petroleum Reservoir Management (MDT) of a Mature Oilfield(2017) Selveindran, Anand; Simone, Alessandra; Chen, J.; Joslin, B.; Narayan, R.; Rendon, C.; Sharma, P.Item An Interactive Application to Relax the Brain Waves(2017) Shirur Sudhakar, LavanyaItem Analysis of the Spatio-Temporal Dynamics of Infection(2017) Stolley, Danielle L.; May, Elebeoba E.Spatio-temporal dynamics are vital in understanding the course of infection, particularly for infections that lead to the formation of granulomas such as Mycobacterium tuberculosis which significantly impact the course of infection. In in vitro studies, the observable data is gathered at the global environment level (a single well), but this lacks the correlation and relationship between an individual cell, its local neighborhood and its global environment. Traditional 2D models of infection allow for easily replication and rapid sampling but, devoid of an extracellular matrix (ECM) are unable to fully replicate the spatial dynamics of an in vivo system. In vivo models, while providing multi-cellular response and spatial dynamics do not allow the freedom of sampling granted in vitro. We aim to develop corresponding in vitro and in silico platforms to adequately capture and analyze the multidimensional nature of immune response to infection. By connecting the in vitro and in silico platforms with confocal imaging, we are able to observe, quantify, and correlate cellular behaviors on all levels and determine the characterizes that lead to different outcomes of infection.Item Articulation and the Flute Duets of Friedrich Kuhlau(2017) Diehl, AlainaGerman-born Danish composer Friedrich Kuhlau (1786-1832) published numerous volumes of flute duet music (Opp. 10, 13b, 39, 80, 81, 87, 102, and 110), which were popular in their time and are still staples in the library of the modern flutist. The examination of articulation within these duets serves as a catalyst to trace the practices and aesthetics of articulation in the early nineteenth century.Item Bioimaging of Flow Dynamics in BTB(2017) Raghunandan, Santhanakrishnan; Alba, Kamran; Ganapathy, SivakumarGloriosa superba is a well-known source of the bioactive colchicine. It is one of the primary sources of treatment for gout and under drug development for cancer as well as cardiovascular diseases. The balloon type bubble bioreactor (BTBR) has been successfully used for the production of biopharmaceuticals. The biomanufacturing of colchicine can be increased by understanding the flow dynamics, mixing intensity inside the BTBR. The preliminary results illustrate the homogenous and heterogeneous flow patterns, the direction of flow inside the reactor at low and high gas injection rates. We will present the mean bubble diameter, the maximum and the minimum vorticity, density of the fluid, viscosity, and surface tension bioimaging as well as quantitative data, which could provide better understanding of the fluid dynamics for the biomanufacturing of biorhizome for therapeutic colchicine production.Item Bioorthogonal Transfer Hydrogenation Mediated by Small Molecule Catalyst(2017) Bose, Sohini; Do, Loi H.Background. Increasing threat of drug resistant diseases. Need of new therapeutic solutions. Most of the drugs available are either organic molecules or biologics. Inorganic metal complexes can undergo ligand exchange reaction. Metal centers exist in different oxidation states and form more than four bonds unlike carbon. Inorganic medicinal chemistry is underexplored. Goal. Engineer unprotected metal catalyst. Carry out bioorthogonal transfer hydrogenation. Challenges. Catalyst should be stable in water, air, biological pH and non toxic. Catalyst should be active in presence of cellular nucleophiles. Benefits. Catalytic drugs do not need in stoichiometric amount. New mechanism may overcome drug resistant problem.Item Borderlands Archives Cartography(2017) Álvarez, Maira E.; Fernández, Sylvia A.BAC emerges from the constant aggressive political rhetoric that displays the geographic and ideological border between the United States and Mexico as a threat. The objective is to uncover newspapers published on the U.S.-Mexico border from 1808-1930.Item Cannabis Terpenes Synergistically Modulate Hippocampal Excitability(2017) Abdulla, Ahmad; Hosseini-Zareh, Mahshid; Ziburkus, JokubasThis work demonstrates how commonly ingested aromatic compounds (terpenes, flavonoids, and odorants) can induce physiological changes on the molecular level in brain regions implicated in high order information processing. Indeed, the component discussed in this study (BCP) is found in relatively high concentrations in common household spices such as cloves and black pepper. Also, limonene is commonly found in the rinds of citrus fruits (e.g. lemon and oranges). These physiological actions could be responsible for individual preferences of different types of foods and aromas that act synergistically with our bodies and modify behavior. Lastly, the need for effective treatments for severe pharmacoresistant forms of pediatric epilepsies such as Dravet syndrome is of imminent importance. Due to current drug laws, it is legally and financially impractical for many people to obtain high quality and high concentration C. sativa extracts. This could lead to ingestion of inferior products with chemical contamination or highly variable concentrations of chemical components. This issue may be completely circumvented by using natural non-cannabis derived cannabinoid agonists. The only limitation is our lack of knowledge and testing regarding these substances.Item Characterization of the Pro-Survival Role of Kinase-Independent EGFR in Cancer(2017) Srivastava, Shivangi; Katreddy, Rajashekara; Thomas, Rintu; Zhang, WeihuaEGFR (Epidermal Growth Factor Receptor), a receptor tyrosine kinase is overexpressed or mutated in a variety of tumors of epithelial origin. Although, its kinase activity is well characterized and is being targeted in the clinic, still patients develop resistance and stop responding to TKIs. Therefore, there is a need to understand the kinase-independent functions of EGFR and how it can be clinically targeted. Here, I describe the work that tests the hypothesis that EGFR independent of its tyrosine kinase activity mediates survival of cancer cells under various physiological stresses and thereby promoting resistance against TKIs.Item Cosmogenic Backgrounds at the Daya Bay Experiment(2017) Mitchell, IanNowadays, the frontier of physics is underground. Experiments like Daya Bay search for rare processes and events, shielded by hundreds of feet of solid rock. But some particles can penetrate through that, while evading our best efforts at tracking them. I am working on measuring their impact on our experiment, and therefore on measurements of the fundamental properties of the cosmos.