Studies on erythrocyte sugar transport

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dc.contributor.advisorMailman, David S.
dc.contributor.committeeMemberKimball, Aubrey P.
dc.contributor.committeeMemberBartel, Allen H.
dc.contributor.committeeMemberHazelwood, Robert L.
dc.contributor.committeeMemberLawrence, Addison Lee
dc.contributor.committeeMemberAumann, Glenn David
dc.creatorNovak, Roger Allan
dc.date.accessioned2022-03-16T15:46:49Z
dc.date.available2022-03-16T15:46:49Z
dc.date.issued1972
dc.description.abstractSugar transport was studied. In bovine and human erythrocytes. It was concluded that the bovine RBC possesses a facilitated diffusion system for the transport of various sugars, based on the demonstration of saturation kinetics and competitive inhibition. However, sugar transport In the bovine RBC, as compared to the human RBC, Is characterized by (1) a slow rate of transport, (2) lack of substrate alteration of carrier mobility, and (3) insensitivity to protein sulfhydryl reagents. Membrane components of the human RBC sugar transport system were Identified by dual Isotopic, differential labeling with 2-fluoro-2,4-dinitrobenzene (DNFB). The labeling technique was based on the ability of high affinity substrates to Induce conformational changes In the transport mechanism, thereby. Increasing Its incorporation of DNFB. The results indicate that, under these conditions, the site of DNFB incorporation is the membranephospholipids, rather than membrane proteln(s). Thus It appears that membrane phospholipids are an integral part of the sugar transport system.
dc.description.departmentBiology and Biochemistry, Department of
dc.format.digitalOriginreformatted digital
dc.format.mimetypeapplication/pdf
dc.identifier.other23160824
dc.identifier.urihttps://hdl.handle.net/10657/8898
dc.language.isoen
dc.rightsThis item is protected by copyright but is made available here under a claim of fair use (17 U.S.C. §107) for non-profit research and educational purposes. Users of this work assume the responsibility for determining copyright status prior to reusing, publishing, or reproducing this item for purposes other than what is allowed by fair use or other copyright exemptions. Any reuse of this item in excess of fair use or other copyright exemptions requires express permission of the copyright holder.
dc.titleStudies on erythrocyte sugar transport
dc.type.dcmiText
dc.type.genreThesis
thesis.degree.collegeCollege of Arts and Sciences
thesis.degree.departmentBiology, Department of
thesis.degree.disciplineBiology
thesis.degree.grantorUniversity of Houston
thesis.degree.levelDoctoral
thesis.degree.nameDoctor of Philosophy

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