Sparse Deconvolution of Pulsatile Growth Hormone Secretion in Adolescents

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dc.contributorFaghih, Rose T.
dc.contributorReddy, Rohith
dc.contributorLong, Stuart A.
dc.contributor.authorGenty, Jon X.
dc.date.accessioned2021-09-16T21:32:12Z
dc.date.available2021-09-16T21:32:12Z
dc.date.issued2020-12
dc.description.abstractGrowth hormone (GH) is secreted by cells in the anterior pituitary on two time scales: discrete pulses over minutes that occur within a 24-hr pattern. Secretion reflects the balance of stimulatory and inhibitory inputs from the hypothalamus and is influenced by gonadal steroids, stress, nutrition, and sleep/wake states. We propose a novel approach for the analysis of GH data and use this approach to quantify (i) the timing, amplitude, and the number of GH pulses and (ii) GH infusion, clearance, and basal secretion (i.e., time-invariant) rates, using serum GH sampled every 10 minutes during an eight-hour sleep study in 18 adolescents. In our method, we approximate hormonal secretory events by deconvolving GH data via a two-step coordinate descent approach. The first step utilizes a sparse-recovery approach to estimate the timing and amplitude of GH secretory events. The second step estimates physiological parameters. Our method identifies the timing and amplitude of GH pulses and system parameters from experimental and simulated data, with a median R2 of 0.93, among experimental data. Recovering GH pulses and model parameters using this approach may improve the quantification of GH parameters under different physiological and pathological conditions and the design and monitoring of interventions.
dc.description.departmentElectrical and Computer Engineering, Department of
dc.description.departmentHonors College
dc.identifier.urihttps://hdl.handle.net/10657/8260
dc.language.isoen
dc.relation.ispartofSenior Honors Theses
dc.rightsThe author of this work is the copyright owner. UH Libraries and the Texas Digital Library have their permission to store and provide access to this work. Further transmission, reproduction, or presentation of this work is prohibited except with permission of the author(s).
dc.subjectBiomedical signal processing
dc.subjectDeconvolution
dc.subjectConstrained optimization
dc.subjectState-space methods
dc.subjectGrowth hormone
dc.subjectPulsatile hormones
dc.titleSparse Deconvolution of Pulsatile Growth Hormone Secretion in Adolescents
dc.typeHonors Thesis
dc.type.dcmiText
thesis.degree.collegeCullen College of Engineering
thesis.degree.levelBachelors
thesis.degree.nameBachelor of Science

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