Synthesis of SOD1-SNAP Fusion Proteins through Molecular Cloning

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dc.contributorChen, Tai-Yen
dc.contributor.authorNguon, Sun Kyung
dc.contributor.authorXie, Xihong
dc.date.accessioned2021-02-23T16:27:14Z
dc.date.available2021-02-23T16:27:14Z
dc.date.issued2019
dc.description.abstractThe development of abnormal metal homeostasis can engender dysfunction of various neural processes and can lead to neurodegenerative diseases. Therefore, metal trafficking is highly regulated in the human body. SOD1 is an antioxidant enzyme that attaches to molecules of copper and zinc and converts reactive oxidant species into less toxic hydrogen peroxide and dioxygen. A mutant form of SOD1 could bring damages to motor neurons and cause neurodegenerative diseases such as ALS. However, the molecular mechanism of this protein is not well understood. In the present study, SOD1 was fused with a tag protein SNAP to be used in a later study of its function and molecular mechanism.
dc.description.departmentBiology and Biochemistry, Department of
dc.description.departmentHonors College
dc.identifier.urihttps://hdl.handle.net/10657/7545
dc.language.isoen_US
dc.relation.ispartofSummer Undergraduate Research Fellowship
dc.rightsThe author of this work is the copyright owner. UH Libraries and the Texas Digital Library have their permission to store and provide access to this work. Further transmission, reproduction, or presentation of this work is prohibited except with permission of the author(s).
dc.titleSynthesis of SOD1-SNAP Fusion Proteins through Molecular Cloning
dc.typePoster

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