Strong Base Mediated Intramolecular Cyclopropanation

dc.contributor	Daugulis, Olafs
dc.contributor.author	Martinez, Andrew
dc.date.accessioned	2022-09-22T20:56:24Z
dc.date.available	2022-09-22T20:56:24Z
dc.date.issued	2022-04-14
dc.description.abstract	The strong base lithium tetramethylpiperidide (LiTMP) was used to introduce a cyclopropane moiety in a minimally functionalized molecule. This new method uses a triflate leaving group to form a carbene intermediate that reacts in a statistical fashion with any adjacent hydrogens to form the cyclopropane structure. Further experimenting with the reaction conditions for functional group tolerance will allow for more complex molecules to be modified in the future. Developing new methods to synthesize cyclopropanes would allow for late-stage modification of existing drugs or natural products to further medicinal research.
dc.description.department	Chemistry, Department of
dc.description.department	Honors College
dc.identifier.uri	https://hdl.handle.net/10657/11736
dc.language.iso	en_US
dc.relation.ispartof	Summer Undergraduate Research Fellowship
dc.rights	The author of this work is the copyright owner. UH Libraries and the Texas Digital Library have their permission to store and provide access to this work. Further transmission, reproduction, or presentation of this work is prohibited except with permission of the author(s).
dc.title	Strong Base Mediated Intramolecular Cyclopropanation
dc.type	Poster

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