Structure determination of noncanonical RNA motifs guided by 1H NMR chemical shifts

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dc.contributor.authorSripakdeevong, Parin
dc.contributor.authorCevec, Mirko
dc.contributor.authorChang, Andrew T.
dc.contributor.authorErat, Michele C.
dc.contributor.authorZiegeler, Melanie
dc.contributor.authorZhao, Qin
dc.contributor.authorFox, George E.
dc.contributor.authorGao, Xiaolian
dc.contributor.authorKennedy, Scott D.
dc.contributor.authorKierzek, Ryszard
dc.contributor.authorNikonowicz, Edward P.
dc.contributor.authorSchwalbe, Harald
dc.contributor.authorSigel, Roland K. O.
dc.contributor.authorTurner, Douglas H.
dc.contributor.authorDas, Rhiju
dc.date.accessioned2019-07-23T21:11:14Z
dc.date.available2019-07-23T21:11:14Z
dc.date.issued3/2/2014
dc.description.abstractStructured noncoding RNAs underlie fundamental cellular processes, but determining their three-dimensional structures remains challenging. We demonstrate that integrating 1H NMR chemical shift data with Rosetta de novo modeling can be used to consistently determine high-resolution RNA structures. On a benchmark set of 23 noncanonical RNA motifs, including 11 'blind' targets, chemical-shift Rosetta for RNA (CS-Rosetta-RNA) recovered experimental structures with high accuracy (0.6–2.0 Å all-heavy-atom r.m.s. deviation) in 18 cases.
dc.identifier10.1038/nmeth.2876
dc.identifier.citationCopyright 2014 Nature methods. This is a post-print version of a published paper available at: https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC3985481&blobtype=pdf. Recommended citation: Sripakdeevong, Parin, Mirko Cevec, Andrew T. Chang, Michèle C. Erat, Melanie Ziegeler, Qin Zhao, George E. Fox et al. "Structure determination of noncanonical RNA motifs guided by 1 H NMR chemical shifts." Nature methods 11, no. 4 (2014): 413. DOI: 10.1038/nmeth.2876. This item has been deposited in accordance with publisher copyright and licensing terms with the author’s permission.
dc.identifier.urihttps://hdl.handle.net/10657/4226
dc.language.isoen_US
dc.publisherNature Methods
dc.titleStructure determination of noncanonical RNA motifs guided by 1H NMR chemical shifts
dc.typeArticle

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