Studies on the periodate oxidation product of [beta]-D-ribosyl-6-methylthiopurine

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dc.contributor.advisorKimball, Aubrey P.
dc.contributor.committeeMemberBartel, Allen H.
dc.contributor.committeeMemberGray, Horace B., Jr.
dc.contributor.committeeMemberMcElrath, Eby N.
dc.creatorLoy, Philip R.
dc.date.accessioned2022-09-23T19:04:26Z
dc.date.available2022-09-23T19:04:26Z
dc.date.copyright1970
dc.date.issued1970
dc.description.abstractThis study is concerned with the oxidation product of 9-ß-D-ribosyl-6-methylthiopurine. The oxidation product was synthesized in several steps from inosine. 6-mercaptopurine riboside was radiolabeled using sulfur-35. The kinetic study of the sulfur-35 exchange was studied. Methylation and oxidation yielded the 9-ß-D-ribosyl-6-methylthiopurine oxidation product. The radiolabeled product was used to study decomposition of the drug in solution as well as binding of the drug to amino acids.
dc.description.departmentBiology and Biochemistry, Department of
dc.format.digitalOriginreformatted digital
dc.format.mimetypeapplication/pdf
dc.identifier.other23157061
dc.identifier.urihttps://hdl.handle.net/10657/11945
dc.language.isoen
dc.rightsThis item is protected by copyright but is made available here under a claim of fair use (17 U.S.C. Section 107) for non-profit research and educational purposes. Users of this work assume the responsibility for determining copyright status prior to reusing, publishing, or reproducing this item for purposes other than what is allowed by fair use or other copyright exemptions. Any reuse of this item in excess of fair use or other copyright exemptions requires express permission of the copyright holder.
dc.subjectß-D-ribosyl-6-methylthiopurine
dc.titleStudies on the periodate oxidation product of [beta]-D-ribosyl-6-methylthiopurine
dc.type.dcmiText
dc.type.genreThesis
dcterms.accessRightsThe full text of this item is not available at this time because it contains documents that are presumed to be under copyright and are accessible only to users who have an active CougarNet ID. This item will continue to be made available through interlibrary loan.
thesis.degree.collegeCollege of Arts and Sciences
thesis.degree.departmentBiophysical Sciences, Department of
thesis.degree.disciplineBiophysical Sciences
thesis.degree.grantorUniversity of Houston
thesis.degree.levelMasters
thesis.degree.nameMaster of Science

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