2-substituted-2-acetamido- N-benzylacetamides : synthesis, spectroscopic and anticonvulsant properties

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dc.contributor.advisorKohn, Harold L.
dc.contributor.advisorDyckes, Douglas F.
dc.contributor.advisorLemke, Thomas L.
dc.creatorLe Gall, Philippe
dc.date.accessioned2024-01-02T20:05:58Z
dc.date.available2024-01-02T20:05:58Z
dc.date.issued1987
dc.description.abstractSelect functionalized amino acid derivatives of the potent anticonvulsant agent [alpha]-acetamido-H-benzylphenylacetamide (68b) and 2-acetamido-H-benzylpropionamide (68a) have been prepared and evaluated. Attention has been focused on the replacement of the [alpha]-phenyl and [alpha]-methyl groups in 68a and 68b by five-membered ring hetereoaromatic moieties, benzo-fused heteroaromatic groups, and simple polar substituents. The synthetic and pharmacological studies revealed several notable findings. First, the use of amidoalkylation procedures using boron trifluoride etherate provided a straightforward and reliable method to introduce an electron-rich heteroaromatic substituent at the a-carbon in the amino acid derivatives. This technology permitted the incorporation of acid sensitive, unsubstituted heteroaromatic compounds (i.e., pyrrole (74). indole (72) and benzofuran (75)) within the molecule. [...]
dc.description.departmentChemistry, Department of
dc.format.digitalOriginreformatted digital
dc.format.mimetypeapplication/pdf
dc.identifier.other18446021
dc.identifier.urihttps://hdl.handle.net/10657/15690
dc.language.isoen
dc.rightsThis item is protected by copyright but is made available here under a claim of fair use (17 U.S.C. Section 107) for non-profit research and educational purposes. Users of this work assume the responsibility for determining copyright status prior to reusing, publishing, or reproducing this item for purposes other than what is allowed by fair use or other copyright exemptions. Any reuse of this item in excess of fair use or other copyright exemptions requires express permission of the copyright holder.
dc.subjectAcetamide
dc.subjectAnticonvulsants
dc.title2-substituted-2-acetamido- N-benzylacetamides : synthesis, spectroscopic and anticonvulsant properties
dc.type.dcmiText
dc.type.genreThesis
thesis.degree.collegeCollege of Natural Sciences and Mathematics
thesis.degree.departmentChemistry, Department of
thesis.degree.disciplineChemistry
thesis.degree.grantorUniversity of Houston
thesis.degree.levelMasters
thesis.degree.nameMaster of Science

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