Polymeric covalently-linked sustained released dosage forms of aspirin ; Investigation of the synthesis of some novel 5-fused heterocyclic ring systems and their potential application in medicinal chemistry
| dc.contributor.advisor | Williams, Louis | |
| dc.contributor.advisor | Martin, Gary E. | |
| dc.contributor.committeeMember | Cates, Lindley A. | |
| dc.contributor.committeeMember | Euler, Kenneth L. | |
| dc.contributor.committeeMember | Benbrook, James R. | |
| dc.creator | Miller, Richard Foster | |
| dc.date.accessioned | 2022-09-23T19:25:12Z | |
| dc.date.available | 2022-09-23T19:25:12Z | |
| dc.date.issued | 1976 | |
| dc.description.abstract | Part I: Solid phase peptide synthesis, reported by Merrifield in 1964, revolutionized the field of peptide synthesis. The advantages inherent to the solid phase procedure have since been applied to the synthesis of a wide variety of biologically important molecules. The unique aspects of polymeric supports have also been exploited to permit the conduct of a wide variety of synthetic reactions which take advantage of the resin support. Recently, these applications have led to the development of a variety of polymeric reagents where the reactive moiety is carried by the resin via a labile covalent linkage. [...] Part II: A number of syntheses of diaryl sulfides have appeared in the chemical literature of the last seventy years. Generally, these procedures have required harsh reaction conditions. The reaction of halonitro-, halodinitro-, and nitrodihalobenzenes to yield a variety of sulfides has been explored by a number of authors. The displacement of nitro groups from a variety of substrates has also been investigated. Specifically, several of these procedures have generated sulfides either as synthetic intermediates or as intended final products. The intermediate upon which this research was focused, 1,3-bis(thiophenyl)-4-nitrobenzene, was synthesized by means of a halo- displacement from halodinitrobenzene and a subsequent nitro- displacement to yield the desired bisulfide. [...] | |
| dc.description.department | Pharmacy, College of | |
| dc.format.digitalOrigin | reformatted digital | |
| dc.format.mimetype | application/pdf | |
| dc.identifier.other | 3713837 | |
| dc.identifier.uri | https://hdl.handle.net/10657/12054 | |
| dc.language.iso | en | |
| dc.rights | This item is protected by copyright but is made available here under a claim of fair use (17 U.S.C. Section 107) for non-profit research and educational purposes. Users of this work assume the responsibility for determining copyright status prior to reusing, publishing, or reproducing this item for purposes other than what is allowed by fair use or other copyright exemptions. Any reuse of this item in excess of fair use or other copyright exemptions requires express permission of the copyright holder. | |
| dc.title | Polymeric covalently-linked sustained released dosage forms of aspirin ; Investigation of the synthesis of some novel 5-fused heterocyclic ring systems and their potential application in medicinal chemistry | |
| dc.type.dcmi | Text | |
| dc.type.genre | Thesis | |
| thesis.degree.college | College of Pharmacy | |
| thesis.degree.department | Pharmacy, College of | |
| thesis.degree.discipline | Pharmacy | |
| thesis.degree.grantor | University of Houston | |
| thesis.degree.level | Masters | |
| thesis.degree.name | Master of Science |
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