Analysis of the SARS-CoV-2 nucleocapsid protein suggests multiple structures suitable for use in vaccine design

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dc.contributorMorrison, Greg
dc.contributorDodero-Rojas, Esteban
dc.contributorOnuchic, José N.
dc.contributor.authorCalderon-Macedo, Alfredo
dc.date.accessioned2023-07-03T19:00:08Z
dc.date.available2023-07-03T19:00:08Z
dc.date.issued2023-04-13
dc.description.abstractSARS-CoV-2 is the virus that causes the Covid-19 respiratory disease. Recently, we developed an aerosol based vaccine strategy using the Spike protein as the main antigen. However, the nucleocapsid protein (N-protein) of this virus is also highly immunogenic and has potential for use as part of a vaccine strategy. Here, we use a combination of Structure-Based Epitope Predictions and Molecular Dynamics Simulations to find and investigate the stability of N-protein epitopes. We observed that the N-protein contains structures that are stable, and thus have potential for use in our new vaccine strategy. ***This project was completed with contributions from Esteban Dodero-Rojas and José N. Onuchic from Rice University.
dc.description.departmentPhysics, Department of
dc.description.departmentHonors College
dc.identifier.urihttps://hdl.handle.net/10657/14727
dc.language.isoen
dc.rightsThe author of this work is the copyright owner. UH Libraries and the Texas Digital Library have their permission to store and provide access to this work. Further transmission, reproduction, or presentation of this work is prohibited except with permission of the author(s).
dc.subjectBiochemistry
dc.titleAnalysis of the SARS-CoV-2 nucleocapsid protein suggests multiple structures suitable for use in vaccine design
dc.typePoster

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