The effect of surface active agents on the rate of disintegration of various antibiotic tablets

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dc.contributor.advisorGupta, V. Das
dc.contributor.committeeMemberWilson, Robert G.
dc.contributor.committeeMemberClay, Michael M.
dc.creatorCarey, Ronald Wayne
dc.date.accessioned2022-06-28T19:13:13Z
dc.date.available2022-06-28T19:13:13Z
dc.date.issued1970
dc.description.abstractThe effect of surface active agents on the disintegration time of various antibiotic tablets has been studied. Disintegration tests were conducted on five different antibiotic tablets, Pen Vee K, Potassium Penicillin G., Neomycin Sulfate, Griseofulvin, and Erythromycin Stearate, using four different types of surface active agents, polysorbate 80, sorbitan monolaurate, benzalkonium chloride, and triethanolamine oleate. It appears that the disintegration time of neomycin sulfate (a salt of a strong acid and a weak base) tablets can be decreased by nonionic surface active agents of low HLB value (sorbitan monolaurate) and by anionic surface active agents (triethanolamine oleate) while the disintegration times of Pen Vee K and potassium penicillin G; (both salts of a weak acid and a strong base) tablets can be decreased by nonionic surface active agents of high HLB value (polysorbate 80) and by cationic surface active agents (benzalkonium chloride). The disintegration time of griseofulvin (not a salt) tablets may be slightly reduced by polysorbate 80. None of the surface active agents studied appears to have a noticeable effect on the disintegration of erythromycin stearate (a salt of a weak acid and a weak base) tablets.
dc.description.departmentPharmacy, College of
dc.format.digitalOriginreformatted digital
dc.format.mimetypeapplication/pdf
dc.identifier.other13805433
dc.identifier.urihttps://hdl.handle.net/10657/10046
dc.language.isoen
dc.rightsThis item is protected by copyright but is made available here under a claim of fair use (17 U.S.C. Section 107) for non-profit research and educational purposes. Users of this work assume the responsibility for determining copyright status prior to reusing, publishing, or reproducing this item for purposes other than what is allowed by fair use or other copyright exemptions. Any reuse of this item in excess of fair use or other copyright exemptions requires express permission of the copyright holder.
dc.titleThe effect of surface active agents on the rate of disintegration of various antibiotic tablets
dc.type.dcmiText
dc.type.genreThesis
thesis.degree.collegeCollege of Pharmacy
thesis.degree.departmentPharmacy, College of
thesis.degree.disciplinePharmacy
thesis.degree.grantorUniversity of Houston
thesis.degree.levelMasters
thesis.degree.nameMaster of Science

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