Pharmacological analysis of the actions of calcium entry blockers, felodipine, nifedipine and verapamil : interactions with pre- and postjunctional alpha adrenoceptors

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dc.contributor.advisorLokhandwala, Mustafa F.
dc.contributor.advisorEikenburg, Douglas C.
dc.contributor.committeeMemberJandhyala, Bhagvan S.
dc.contributor.committeeMemberAlam, Maktoob
dc.creatorPeter, Eno-Obong J.
dc.date.accessioned2024-04-22T20:17:47Z
dc.date.available2024-04-22T20:17:47Z
dc.date.issued1984
dc.description.abstractThe objective of the present study was to investigate the role of the autonomic nervous system in the hypotensive actions of the calcium entry blockers, felodipine, nifedipine and verapamil. Experiments were designed to determine the effects of these compounds on vascular sympathetic neuroeffector function under both in vivo and in vitro conditions. Intravenous administration of cumulative doses of felodipine in intact urethane anesthetized rats produced a sustained and significant decrease in arterial pressure up to 60 minutes in duration at the highest dose (0.8 [micromol]/kg) tested. Higher doses of nifedipine (0.9 [micromol]/kg) and verapamil (0.9 [micromol]/kg) produced transient but significant decreases in mean blood pressure which lasted for 10 minutes. When cardiac compensation was prevented by either bilateral vagotomy plus atropine (1 mg/kg) or propranolol (1 mg/kg) alone or bilateral vagotomy together with atropine plus propranolol, nifedipine and verapamil were also able to reduce arterial pressure. However after ganglionic blockade (chlorisondamine plus atropine) only felodipine was effective in lowering arterial blood pressure. In pithed rat preparations felodipine (0.5 [micromol]/kg), nifedipine (1.2 [micromol]/kg) and verapamil (0.9 [micromol]/kg) significantly attenuated pressor responses to spinal sympathetic stimulation and exogenous norepinephrine. While all three agents attenuated blood pressure responses to norepinephrine as well as spinal stimulation, felodipine appeared to be more effective in reducing pressor responses to intravenous norepinephrine than those of spinal stimulation. [...]
dc.description.departmentPharmacy, College of
dc.format.digitalOriginreformatted digital
dc.format.mimetypeapplication/pdf
dc.identifier.other11680121
dc.identifier.urihttps://hdl.handle.net/10657/17039
dc.language.isoen
dc.rightsThis item is protected by copyright but is made available here under a claim of fair use (17 U.S.C. Section 107) for non-profit research and educational purposes. Users of this work assume the responsibility for determining copyright status prior to reusing, publishing, or reproducing this item for purposes other than what is allowed by fair use or other copyright exemptions. Any reuse of this item in excess of fair use or other copyright exemptions requires express permission of the copyright holder.
dc.subjectCalcium--Antagonists
dc.subjectCalcium--Physiological effect
dc.subjectAdrenaline--Receptors
dc.titlePharmacological analysis of the actions of calcium entry blockers, felodipine, nifedipine and verapamil : interactions with pre- and postjunctional alpha adrenoceptors
dc.type.dcmiText
dc.type.genreThesis
thesis.degree.collegeCollege of Pharmacy
thesis.degree.departmentPharmacy, College of
thesis.degree.disciplinePharmacy
thesis.degree.grantorUniversity of Houston
thesis.degree.levelMasters
thesis.degree.nameMaster of Science

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