Overproduction and regulation of repressor of phage P22 in polymyxin B-sensitive mutants of Salmonella typhimurium

dc.contributor.advisorGoldschmidt, Eugene P.
dc.contributor.committeeMemberSnider, Philip J.
dc.contributor.committeeMemberKimball, Aubrey P.
dc.contributor.committeeMemberAumann, Glenn David
dc.contributor.committeeMemberEvans, John E.
dc.creatorTokuno, Shin-ichi
dc.description.abstractTwo polymyxin B-sensitive (POX) mutants of Salmonella typhimurium were isolated. One of these mutants, POX-1, proved abnormal in supporting replication of the wild-type phage P22. Compared to the parental host strain, wild-type -4 virus has a very low efficiency of plating (10-4) on the POX-1 mutant, while the C1 and C2 mutants plate with the same efficiency on both host strains. The growth of wild-type phage P22 occurred in the lysogen POX-1 (P22 C+) after UV induction and in C+ infected, POX-1 cells preirradiated with UV light. These results indicate that the POX-1 host is not functionally defective at any stage leading to the normal development of phage P22. The hypothesis favored for the inability of the wild-type virus to multiply in the POX-1 host is the overproduction of repressor by the wild type P22. [...]
dc.description.departmentBiology and Biochemistry, Department of
dc.format.digitalOriginreformatted digital
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dc.titleOverproduction and regulation of repressor of phage P22 in polymyxin B-sensitive mutants of Salmonella typhimurium
dcterms.accessRightsThe full text of this item is not available at this time because it contains documents that are presumed to be under copyright and are accessible only to users who have an active CougarNet ID. This item will continue to be made available through interlibrary loan.
thesis.degree.collegeCollege of Arts and Sciences
thesis.degree.departmentBiology, Department of
thesis.degree.grantorUniversity of Houston
thesis.degree.nameDoctor of Philosophy


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