Comparison between package insert 'full disclosure' suggested utilization of selected intravenous antibiotics with patient chart indications and contraindications

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dc.contributor.advisorGibson, J. Tyrone
dc.contributor.committeeMemberBrown, Kenneth W.
dc.contributor.committeeMemberClay, Michael M.
dc.contributor.committeeMemberKroeger, Ruth C.
dc.contributor.committeeMemberNewton, David S.
dc.creatorHanley, Elizabeth Evans
dc.date.accessioned2022-09-19T16:28:03Z
dc.date.available2022-09-19T16:28:03Z
dc.date.copyright1972
dc.date.issued1972
dc.description.abstractNeed for drug utilization review studies has been indicated by research showing irrational utilization of drugs, ranging from misuse to abuse. The primary purpose of this study is to compare utilization of selected intravenous antibiotics as found in patient chart indications with indications listed in appropriate package inserts. Secondarily, it is to study prescribing patterns of physicians for relationships between variables of patient race, sex, pay status and attending physician training status. Furthermore, this work will provide a foundation for similar drug utilization studies. The study hospital was an over-500 bed, short term, general, non-profit institution. Patients receiving intravenous antibiotics were identified and a chart-review system was used to obtain data. Based upon preliminary data, charts of patients receiving ampicillin or cephalothin were chosen to review. When all data was collected, it was determined whether or not the antibiotic was given: (1) prophylactically, or (2) 'for cause' and whether or not there was agreement with package insert indications. Contraindications were also reviewed to determine agreement. Findings indicate 29.4% of the therapy studied is in agreement with package insert indications, combining prophylactic and disagreement scores. This is significant from chance at the .05 level using chi square. Disregarding prophylactic therapy, 56.4% is in agreement. This is not significant from chance at the .05 level using chi square. Of the therapy studied, 92.8% is in agreement with package insert contraindications. This is significant from chance at the .05 level using chi square. Factorial analysis of variance of the dependent variable agreement scores and independent variables of patient race, sex, pay status and attending physician training status showed significant differences only for the last two variables listed.
dc.description.departmentPharmacy, College of
dc.format.digitalOriginreformatted digital
dc.format.mimetypeapplication/pdf
dc.identifier.other13685764
dc.identifier.urihttps://hdl.handle.net/10657/11385
dc.language.isoen
dc.rightsThis item is protected by copyright but is made available here under a claim of fair use (17 U.S.C. Section 107) for non-profit research and educational purposes. Users of this work assume the responsibility for determining copyright status prior to reusing, publishing, or reproducing this item for purposes other than what is allowed by fair use or other copyright exemptions. Any reuse of this item in excess of fair use or other copyright exemptions requires express permission of the copyright holder.
dc.subjectDrugs--Labeling.
dc.subjectAntibiotics.
dc.subjectPharmacy--Information services--Evaluation.
dc.titleComparison between package insert 'full disclosure' suggested utilization of selected intravenous antibiotics with patient chart indications and contraindications
dc.type.dcmiText
dc.type.genreThesis
dcterms.accessRightsThe full text of this item is not available at this time because it contains documents that are presumed to be under copyright and are accessible only to users who have an active CougarNet ID. This item will continue to be made available through interlibrary loan.
thesis.degree.collegeCollege of Pharmacy
thesis.degree.departmentPharmacy, College of
thesis.degree.disciplinePharmacy
thesis.degree.grantorUniversity of Houston
thesis.degree.levelMasters
thesis.degree.nameMaster of Science

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