Investigation of LRG-I as A Biomarker For Stress Urinary Incontinence In A Rabbit Model?

Stress Urinary Incontinence (SUI) is a condition that primarily affects females, with a prevalence ranging from 15% to 80% (Koch). To develop new treatments for SUI, appropriate animal models must be used to investigate proposed treatments. Previous research have reported elevated levels of LRG-I (logFC 3.91) (Mitulovi?, Koch, etc) in women with SUI compared to healthy women1,2. This study investigates LRG-I concentration in the female New Zealand White rabbit animal model, which has previously been reported as a model for SUI (Corona-Quintanilla). This study aims to determine whether LRG-I is a viable biomarker for SUI in female New Zealand White rabbits. Additionally, LRG-I serum concentrations are compared between old multiparous animals that have undergone neuromodulation treatment and those that have not investigated the effect of treatment.