Novel Protein Biomarkers in Serum for Lupus Nephritis in Adult Patients



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Systemic Lupus Erythematosus (SLE) is an autoimmune disorder where the body’s immune system attacks its own organ systems. This chronic inflammatory disease can effect different body systems like the skin, joints and kidneys. Lupus Nephritis (LN) is the inflammation of the kidney which occurs due to SLE. Lupus nephritis manifests when SLE involves the kidneys. Protein biomarkers provide a more efficient method of diagnosing and detecting LN. The current primary diagnostic tool used is renal biopsy which is expensive and invasive. Concurrent serum samples were obtained from Dr. Saxena from UTSW- for these serum samples we have access to biopsy data. These samples were assayed for levels of proteins IGFBP2, IGFBP4, and sTNFR2. In previous studies these proteins have been shown to be elevated in LN patients. Enzyme Linked Immunosorbent Assays were done to assay protein levels.