Studies on rat cardiovascular monoamine oxidase activity

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dc.contributor.committeeMemberClarke, David E.
dc.contributor.committeeMemberHazelwood, Robert L.
dc.contributor.committeeMemberMailman, David S.
dc.contributor.committeeMemberWagner, Lorin A.
dc.contributor.committeeMemberBuckley, Joseph P.
dc.creatorDial, Elizabeth Jane Samson
dc.date.accessioned2022-12-20T20:39:22Z
dc.date.available2022-12-20T20:39:22Z
dc.date.issued1978
dc.description.abstractStudies were performed to determine the characteristics of rat cardiac monoamine oxidase (MAO) activity. Rat major blood vessels were also examined, since the coronary vasculature constitutes a significant portion of cardiac tissue. MAO is known to exist in two types, A and B, as determined by the inhibitor clorgyline. However, rat heart MAO is claimed to differ radically from that found in other tissues and a multiplicity of MAO activities within the A and B types has been postulated. Thus, a comparison was made between rat heart MAO with that of the rat vas deferens and human cardiovascular tissues. Rat cardiac and vas deferens MAO activity revealed no major differences regarding apparent Km values, inhibitor sensitivity (with the exception of pargyline), or mixed substrate interactions using kynuramine as the substrate. However, rat major blood vessels contained MAO activities which varied in substrate and inhibitor selectivity. While the rat heart had predominantly type A activity, the blood vessels contained type A and a cl orgy 1 ine-resistant species. In contrast, the rat vas deferens had approximately equal amounts of A and B activity. The large A:B ratio in the rat heart explains why many MAO substrates are metabolized only by type A in that organ. [...]
dc.description.departmentBiology and Biochemistry, Department of
dc.format.digitalOriginreformatted digital
dc.format.mimetypeapplication/pdf
dc.identifier.other4727759
dc.identifier.urihttps://hdl.handle.net/10657/13073
dc.language.isoen
dc.rightsThis item is protected by copyright but is made available here under a claim of fair use (17 U.S.C. Section 107) for non-profit research and educational purposes. Users of this work assume the responsibility for determining copyright status prior to reusing, publishing, or reproducing this item for purposes other than what is allowed by fair use or other copyright exemptions. Any reuse of this item in excess of fair use or other copyright exemptions requires express permission of the copyright holder.
dc.titleStudies on rat cardiovascular monoamine oxidase activity
dc.type.dcmiText
dc.type.genreThesis
thesis.degree.collegeCollege of Natural Sciences and Mathematics
thesis.degree.departmentBiology, Department of
thesis.degree.disciplineBiology
thesis.degree.grantorUniversity of Houston
thesis.degree.levelDoctoral
thesis.degree.nameDoctor of Philosophy

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