Fibrotic Response of Device Implantation on the Sciatic Nerve of Rats

The use of implantable devices for neuromodulation has the potential to revolutionize the treatment of various neurological disorders. However, one of the main challenges associated with implantable devices is the foreign body response, which can lead to fibrotic tissue growth and potentially impair the long-term viability of the device. Fibrosis may also indicate that the body is accepting the device and integrating it within itself. In this study, we investigated the foreign body response of fibrosis surrounding the electrode implant area in the sciatic nerve of rats 30 days after device implantation.