ATP and polyphosphoinositide metabolism in normal and diabetic peripheral nerve

dc.contributor.committeeMemberEichberg, Joseph E.
dc.contributor.committeeMemberBartel, Allen H.
dc.contributor.committeeMemberHazelwood, Robert L.
dc.contributor.committeeMemberWidger, William R.
dc.creatorChu, Hsi
dc.description.abstractPolyphosphoinositides (PPI) play an important role in tissue activity and PPI metabolism is altered in experimental diabetic neuropathy. Previous studies have shown that 32P incorporation is significantly increased into phosphatidylinositol-4,5-bisphosphate (PIP2) in sciatic nerve from streptozotocin-diabetic rats. It was also found that uptake of 32P into PIP2 in the proximal portion was more than 80% higher than in the distal portion of sciatic nerve and the altered metabolism of this lipid was predominantly associated with the distal portion in the diabetic states. The aims of the present study were to compare the metabolic characteristics of ATP and PIP2 and to investigate whether alterations in the precursor ATP pool could account for the changes in PIP2 labeling in diabetic nerve. [...]
dc.description.departmentBiology and Biochemistry, Department of
dc.format.digitalOriginreformatted digital
dc.rightsThis item is protected by copyright but is made available here under a claim of fair use (17 U.S.C. Section 107) for non-profit research and educational purposes. Users of this work assume the responsibility for determining copyright status prior to reusing, publishing, or reproducing this item for purposes other than what is allowed by fair use or other copyright exemptions. Any reuse of this item in excess of fair use or other copyright exemptions requires express permission of the copyright holder.
dc.subjectAdenosine triphosphate--Metabolism
dc.titleATP and polyphosphoinositide metabolism in normal and diabetic peripheral nerve
dc.type.genreThesis of Natural Sciences and Mathematics and Biophysical Sciences, Department of and Biophysical Sciences of Houston of Science


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