Analysis of Early Myelin Development in the Central Nervous System



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Myelin, produced by oligodendrocytes (OLGs), is the major factor for the stability of neural transmission in the central nervous system (CNS). The interaction between axons and OLGs has been of interest in determining factors to increase myelination. This study aims to examine genes that may be responsible for this increase in early postnatal development. Expression level results show that genes responsible for mitochondrial transport protein stability and axonal outgrowth (MIRO1 and TRIO, respectively) were significant in early postnatal development, while the gene involved in OLG process extension through actin cytoskeletal rearrangement was significant in late postnatal development (ERMN). Results from this study can serve as preliminary data for others studies concerning factors affecting myelination, with applications to treatment of de-myelinating diseases such as multiple sclerosis. This project was completed with contributions from Philip Horner, Scientific Director for the Center for Neuroregneration at the Houston Methodist Research Institute.