Development of improved inhibitors of wall teichoic acid biosynthesis with potent activity against Staphylococcus aureus

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dc.contributor.authorLee, Kyungae
dc.contributor.authorCampbell, Jennifer
dc.contributor.authorSwoboda, Jonathan G.
dc.contributor.authorCuny, Gregory D.
dc.contributor.authorWalker, Suzanne
dc.date.accessioned2020-03-10T17:31:53Z
dc.date.available2020-03-10T17:31:53Z
dc.date.issued2011-03
dc.description.abstractA small molecule (1835F03) that inhibits Staphylococcus aureus wall teichoic acid biosynthesis, a proposed antibiotic target, has been discovered. Rapid, parallel, solution-phase synthesis was employed to generate a focused library of analogs, providing detailed information about structure–activity relationships and leading to the identification of targocil, a potent antibiotic.
dc.identifier.citationCopyright 2011 Bioorganic and Medicinal Chemistry Letters. This is a post-print version of a published paper that is available at: https://www.sciencedirect.com/science/article/pii/S0960894X1000048X. Recommended citation: Lee, Kyungae, Jennifer Campbell, Jonathan G. Swoboda, Gregory D. Cuny, and Suzanne Walker. "Development of improved inhibitors of wall teichoic acid biosynthesis with potent activity against Staphylococcus aureus." Bioorganic & medicinal chemistry letters 20, no. 5 (2010): 1767-1770.This item has been deposited in accordance with publisher copyright and licensing terms and with the author's permisson.
dc.identifier.urihttps://hdl.handle.net/10657/5967
dc.language.isoen_US
dc.publisherBioorganic and Medicinal Chemistry Letters
dc.subjectwall teichoic acids (WTAs)
dc.subjectstaphylococcus aureus
dc.subjectBacteriostatic
dc.subjectstructure acivity relationship (SAR)
dc.subjecttriazoloquinazoline
dc.subjecttargocil
dc.titleDevelopment of improved inhibitors of wall teichoic acid biosynthesis with potent activity against Staphylococcus aureus
dc.typeArticle

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