Estrogen and ER?: Culprits in Cervical Cancer?



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Trends in Endocrinology and Metabolism


Estrogen and its receptors are implicated in the promotion and prevention of various cancers. While the uterine cervix is highly responsive to estrogen, the role of estrogen in cervical cancer, which is strongly associated with human papillomavirus (HPV) infections, is poorly understood. Recent studies in HPV transgenic mouse models provide evidence that estrogen and its nuclear receptor promote cervical cancer in combination with HPV oncogenes. While epidemiological studies further support this hypothesis, there is little experimental data assessing the hormonal responsiveness of human cervical cancers. If these cancers are dependent upon estrogen, then drugs targeting estrogen and its receptors may be effective in treating and/or preventing cervical cancer, the second leading cause of death by cancer amongst women worldwide.




Copyright 2010 Trends in Endocrinology & Metabolism. This is a post-print version of a published paper that is available at: Recommended citation: Chung, Sang-Hyuk, Silvia Franceschi, and Paul F. Lambert. "Estrogen and ER?: Culprits in cervical cancer?." Trends in Endocrinology & Metabolism 21, no. 8 (2010): 504-511. DOI: 10.1016/j.tem.2010.03.005. This item has been deposited in accordance with publisher copyright and licensing terms and with the author's permission.