The effect of the E7 oncoprotein and PKM2 on the growth of HPV-induced cervical cancer

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dc.contributorChung, Sang-Hyuk
dc.contributor.authorTroxler, Madison
dc.date.accessioned2021-02-23T16:30:28Z
dc.date.available2021-02-23T16:30:28Z
dc.date.issued2019
dc.description.abstractHuman papillomavirus (HPV) is a sexually transmitted infection (STI) that affects a huge proportion of the global population. High-risk HPVs lead to cervical cancer, which proves fatal for many patients. One of the major proteins related to the increased cell growth of high-risk strains is E7. Furthermore, the high-risk type HPV16 has been found to interact with the key metabolic enzyme pyruvate kinase M2 (PKM2), which is thought to contribute to increased cancerous growth. This project examines the influence of HPV16 E7 on the activation of three transcription factors known to be relevant in the growth of other forms of cancer: phospho-YAP, phospho-STAT3, and B-catenin. Beta-catenin was not found at increased levels when E7 was present, while phospho-YAP was found in larger proportions as a result of E7 influence. STAT3 had inconclusive results for its interaction with E7 but did show a decrease in transcription factor activation when PKM2 was knocked out in the cell line. YAP similarly showed decreased activation in the PKM2 knockout samples.
dc.description.departmentBiology and Biochemistry, Department of
dc.description.departmentHonors College
dc.identifier.urihttps://hdl.handle.net/10657/7571
dc.language.isoen_US
dc.relation.ispartofSummer Undergraduate Research Fellowship
dc.rightsThe author of this work is the copyright owner. UH Libraries and the Texas Digital Library have their permission to store and provide access to this work. Further transmission, reproduction, or presentation of this work is prohibited except with permission of the author(s).
dc.titleThe effect of the E7 oncoprotein and PKM2 on the growth of HPV-induced cervical cancer
dc.typePoster

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