The synthesis of some p-substituted benzenesulfonyl guanidines

Simple item page
dc.contributor.advisorBoblitt, Robert L.
dc.contributor.committeeMemberCates, Lindley A.
dc.contributor.committeeMemberNelson, Robert G.
dc.contributor.committeeMemberMcElrath, Eby N.
dc.creatorNicholas, Nickie Lee
dc.date.accessioned2022-06-28T19:13:20Z
dc.date.available2022-06-28T19:13:20Z
dc.date.issued1966
dc.description.abstractIn view of the structural similarity of urea and guanidine combined with the fact that certain derivatives of sulfonylurea have been found to be active as oral hypogycemic agents, it seemed desirable to prepare several p-substituted benzenesulfonyl guanidines for further testing as hypoglycemic agents. The synthesis of p-cyanobenzenesulfonyl cyclohexylguanidine was performed by direct condensation of equal molar quanities of p-cyanobenzenesulfonyl chloride with cyclohexylguanidine hydrochloride in an aqueous-acetone solution. Also p-cyanobenzenesulfonyl n-butylguanidine was synthesized by the same procedure. The imino-ester hydrochloride was prepared from p-cyanobenzenesulfonyl cyclohexylguanidine by saturating a solution of the nitrile in ether and absolute ethanol at room temperature with dry hydrogen chloride. The p-N-n-propyl carbamidino was then prepared from the iminoester hydrochloride; i.e., N' - [(p-carbethoxyimino) benzenesulfonyl] cyclohexylguanidine hydrochloride.
dc.description.departmentPharmacy, College of
dc.format.digitalOriginreformatted digital
dc.format.mimetypeapplication/pdf
dc.identifier.other13805616
dc.identifier.urihttps://hdl.handle.net/10657/10058
dc.language.isoen
dc.rightsThis item is protected by copyright but is made available here under a claim of fair use (17 U.S.C. Section 107) for non-profit research and educational purposes. Users of this work assume the responsibility for determining copyright status prior to reusing, publishing, or reproducing this item for purposes other than what is allowed by fair use or other copyright exemptions. Any reuse of this item in excess of fair use or other copyright exemptions requires express permission of the copyright holder.
dc.titleThe synthesis of some p-substituted benzenesulfonyl guanidines
dc.type.dcmiText
dc.type.genreThesis
thesis.degree.collegeCollege of Pharmacy
thesis.degree.departmentPharmacy, College of
thesis.degree.disciplinePharmacy
thesis.degree.grantorUniversity of Houston
thesis.degree.levelMasters
thesis.degree.nameMaster of Science

Files

Original bundle

Now showing 1 - 1 of 1
Thumbnail Image
Name:
Nicholas_1966_13805616.pdf
Size:
674.8 KB
Format:
Adobe Portable Document Format
Download

Collections

Legacy Theses and Dissertations (1940-2009)