Prospective and episodic memory in relation to hippocampal volume in adults with spina bifida myelomeningocele


The present study examined prospective and episodic memory in relation to age, functional independence, and hippocampal volume in younger to middle-aged adults with spina bifida myelomeningocele (SBM) and typically developing (TD) adults. Prospective and episodic memory, as well as hippocampal volume, was reduced in adults with SBM relative to TD adults. Neither memory performance nor hippocampal volume showed greater decrements in older adults. Lower hippocampal volume was associated with reduced prospective memory in adults with SBM, and this relation was specific to the hippocampus and not to a contrast structure, the amygdala. Prospective memory mediated the relation between hippocampal volume and functional independence in adults with SBM. The results add to emerging evidence for reduced memory function in adults with SBM and provide quantitative evidence for compromised hippocampal macrostructure as a neural correlate of reduced memory in this population.

Aging, Hippocampus, Memory, Neurodevelopmental Disorder, Spina bifida myelomeningocele
Copyright 2015 Neuropsychology. This is a post-print version of a published paper that is available at: Recommended citation: Treble-Barna, Amery, Jenifer Juranek, Karla K. Stuebing, Paul T. Cirino, Maureen Dennis, and Jack M. Fletcher. "Prospective and Episodic Memory in Relation to Hippocampal Vol. in Adults with Spina Bifida Myelomeningocele." Neuropsychology 29, no. 1 (2015): 92-101. doi: 10.1037/neu0000111. This item has been deposited in accordance with publisher copyright and licensing terms and with the author's permission.