Development Of A High-Throughput Flow Biofilm Reactor System For The Study of Bacterial Interference Against Uropathogenic Colonization On Silicone Urinary Catheters

In this project, a 34-channel catheter array system was designed to investigate our bacterial interference strategy under in vivo flow conditions. The catheter model system consists of three main parts: an ultraviolet (UV) disinfection subsystem; a 100L artificial urine preparation, storage, and flow guiding subsystem; and a 34-channel catheter array. This catheter-model project opens vast possibilities toward studying the interactions among nonpathogenic and pathogenic bacteria involved in CAUTI and its prevention based on the bacterial interference strategy.