Inhibition of Fatty Acid Amide Hydrolase Increases Rates of Apoptosis in Cell Line Models of DLBCL and Breast Cancer

Simple item page
dc.contributor.advisorMohan, Chandra
dc.contributor.committeeMemberOmurtag, Ahmet
dc.contributor.committeeMemberFrigo, Daniel E.
dc.creatorHenderson, Jared
dc.creator.orcid0000-0002-5121-5234
dc.date.accessioned2018-11-30T21:39:46Z
dc.date.available2018-11-30T21:39:46Z
dc.date.createdAugust 2016
dc.date.issued2016-08
dc.date.submittedAugust 2016
dc.date.updated2018-11-30T21:39:46Z
dc.description.abstractDespite recent advances in cancer treatment, cancers with high heterogeneity such as DLBCL and breast cancer remain difficult to treat, with many patients having few treatment options. The endocannabinoid system has been identified as a potential wellspring of therapeutic agents that can potentially increase cell death and prevent metastasis. Since FAAH is a hydrolytic enzyme that degrades potentially therapeutic endocannabinoids, FAAH inhibitors were tested as apoptosis inducing agents based on their ability to prevent endocannabinoid degradation. In this study, multiple human DLBCL and breast cancer cell lines were treated with FAAH inhibitors, then tested for apoptosis via flow cytometry or with MTT viability testing. DLBCL lines treated with FAAH inhibitors induced apoptosis at dramatically higher rates than vehicle control, and breast cancer cell lines show potential for use of FAAH inhibitors to dramatically decrease cell viability. FAAH inhibition may prove useful as a combination therapeutic for DLBCL or breast cancer.
dc.description.departmentBiomedical Engineering, Department of
dc.format.digitalOriginborn digital
dc.format.mimetypeapplication/pdf
dc.identifier.urihttp://hdl.handle.net/10657/3576
dc.language.isoeng
dc.rightsThe author of this work is the copyright owner. UH Libraries and the Texas Digital Library have their permission to store and provide access to this work. Further transmission, reproduction, or presentation of this work is prohibited except with permission of the author(s).
dc.subjectFAAH
dc.subjectFatty Acid Amide Hydrolase
dc.subjectDLBCL
dc.subjectBreast cancer
dc.subjectCB1
dc.subjectCB2
dc.subjectEndocannabinoids
dc.subjectApoptosis
dc.subjectURB 597
dc.titleInhibition of Fatty Acid Amide Hydrolase Increases Rates of Apoptosis in Cell Line Models of DLBCL and Breast Cancer
dc.type.dcmiText
dc.type.genreThesis
thesis.degree.collegeCullen College of Engineering
thesis.degree.departmentBiomedical Engineering, Department of
thesis.degree.disciplineBiomedical Engineering
thesis.degree.grantorUniversity of Houston
thesis.degree.levelMasters
thesis.degree.nameMaster of Science

Files

Original bundle

Now showing 1 - 1 of 1
Thumbnail Image
Name:
HENDERSON-THESIS-2016.pdf
Size:
1.49 MB
Format:
Adobe Portable Document Format
Download

License bundle

Now showing 1 - 1 of 1
No Thumbnail Available
Name:
LICENSE.txt
Size:
1.82 KB
Format:
Plain Text
Description:
Download

Collections

Published ETD Collection