Discovery and Validation of IgG4 Anti-Gliadin Autoantibody as a Disease Marker of Psoriasis

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dc.contributor.advisorWu, Tianfu
dc.contributor.committeeMemberMohan, Chandra
dc.contributor.committeeMemberZhang, Yingchun
dc.creatorQiu, Jingyi
dc.date.accessioned2018-11-30T18:13:48Z
dc.date.available2018-11-30T18:13:48Z
dc.date.createdMay 2018
dc.date.issued2018-05
dc.date.submittedMay 2018
dc.date.updated2018-11-30T18:13:48Z
dc.description.abstractAntigen microarray is a high-throughput technology, which can be used to select potential biomarkers. In this paper, antigen microarray is the main technology used to determine potential autoantibody biomarkers in different diseases: psoriasis and breast cancer. IgG subtype and IgG total were used as secondary antibodies to bind autoantibodies in patients’ serum, for psoriasis and breast cancer respectively. The enzyme-linked immunosorbent assay (ELISA) was adopted to measure serum level of the potential autoantibodies in a large number of serum samples from patients and healthy controls. These studies have revealed IgG4 anti-human gliadin autoantibody as a potential novel biomarker of psoriasis.
dc.description.departmentBiomedical Engineering, Department of
dc.format.digitalOriginborn digital
dc.format.mimetypeapplication/pdf
dc.identifier.urihttp://hdl.handle.net/10657/3506
dc.language.isoeng
dc.rightsThe author of this work is the copyright owner. UH Libraries and the Texas Digital Library have their permission to store and provide access to this work. Further transmission, reproduction, or presentation of this work is prohibited except with permission of the author(s).
dc.subjectAntigen array
dc.subjectPsoriasis
dc.subjectBiomarkers
dc.titleDiscovery and Validation of IgG4 Anti-Gliadin Autoantibody as a Disease Marker of Psoriasis
dc.type.dcmiText
dc.type.genreThesis
local.embargo.lift2020-05-01
local.embargo.terms2020-05-01
thesis.degree.collegeCullen College of Engineering
thesis.degree.departmentBiomedical Engineering, Department of
thesis.degree.disciplineBiomedical Engineering
thesis.degree.grantorUniversity of Houston
thesis.degree.levelMasters
thesis.degree.nameMaster of Science

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