Cortical Thickness and Gyrification in Children with Developmental Dyslexia

dc.contributor.advisorFletcher, Jack M.
dc.contributor.committeeMemberJuranek, Jenifer
dc.contributor.committeeMemberStuebing, Karla K.
dc.contributor.committeeMemberSharp, Carla
dc.creatorWilliams, Victoria 2015 2015
dc.description.abstractPrior research has demonstrated a pattern of atypical neural structure and function within regions of the left hemisphere reading network in individuals with dyslexia compared to controls. However, studies of pediatric dyslexia are sparse, demonstrate variability in dyslexia classification, and yield inconsistent associations between cortical metrics and reading ability. This study investigated cortical metrics in typically developing readers (n=39) and children with dyslexia (n=37) as determined by deficient single word reading ability. Whole-brain vertex-wise analyses, performed using FreeSurfer, evaluated cortical thickness and local gyrification between reading groups, controlling for age. Following multiple comparison correction, readers with dyslexia demonstrated reduced cortical thickness within previously identified critical reading areas including: bilateral inferior-temporal, inferior-frontal, and occipito-parietal regions, along with left anterior cingulate cortex. In readers with dyslexia, thinner cortex was accompanied by increased gyrification in the cuneus and left inferior temporal cortex. The convergence of thinner and more gyrified cortex within the left inferior temporal region in children with dyslexia may reflect its early temporal role in processing word forms, and highlights the importance of the ventral stream for successful decoding. Reading fluency scores demonstrated a positive association with cortical thickness in right inferior frontal and bilateral inferior temporal cortices, while reading comprehension was significantly correlated with thickness across all regions.
dc.description.departmentPsychology, Department of
dc.format.digitalOriginborn digital
dc.rightsThe author of this work is the copyright owner. UH Libraries and the Texas Digital Library have their permission to store and provide access to this work. Further transmission, reproduction, or presentation of this work is prohibited except with permission of the author(s).
dc.subjectDevelopmental dyslexia
dc.subjectCortical thickness
dc.subjectSingle word reading
dc.subjectStructural neuroimaging
dc.subjectDevelopmental disorder
dc.titleCortical Thickness and Gyrification in Children with Developmental Dyslexia
dc.type.genreThesis of Liberal Arts and Social Sciences, Clinical of Houston of Philosophy


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