Identification and Quantitation of Novel Urinary Biomarkers of Lupus Nephritis

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dc.contributor.advisorMohan, Chandra
dc.contributor.committeeMemberBuhrman, Jonathan
dc.contributor.committeeMemberMajd, Sheereen
dc.contributor.committeeMemberShevkoplyas, Sergey S.
dc.contributor.committeeMemberWu, Tianfu
dc.creatorStanley, Samantha
dc.creator.orcid0000-0002-3173-6825
dc.date.accessioned2019-05-23T13:16:04Z
dc.date.createdAugust 2018
dc.date.issued2018-08
dc.date.submittedAugust 2018
dc.date.updated2019-05-23T13:16:05Z
dc.description.abstractSystemic lupus erythematosus (SLE) is a chronic autoimmune disorder in which the body produces anti-ds DNA and anti-nuclear antibodies and leads to multi-system inflammation and tissue damage. One of the leading causes of mortality and morbidity of SLE is lupus nephritis (LN), a condition where SLE begins to manifest within the renal tissue; it has been estimated that more than half of all SLE patients will develop LN and 10-15% of those patients will experience end-stage renal failure. Early-stage disease diagnosis could allow for earlier treatment and preventative measures to be taken but is not presently possible because the currently used laboratory tests only detect disease activity at a severe stage, and the current gold standard of care to analyze renal involvement in SLE is a renal biopsy. While renal biopsies are highly informative, they cannot be performed routinely, and come with several risks to the patient, including the highly invasive nature of the procedure, the risk of infection, and the possibility of sampling error that the biopsy taken is not representative of the entire kidney. The need for earlier diagnostic tools for LN has sparked a large research interest in urine proteins to identify a noninvasive biomarker specific to LN, but insofar no ideal biomarker has been identified. Thus, the overall goal of this thesis is to identify new urinary biomarkers for lupus nephritis and assess various detection technologies and their effectiveness at measuring urinary proteins.
dc.description.departmentBiomedical Engineering, Department of
dc.format.digitalOriginborn digital
dc.format.mimetypeapplication/pdf
dc.identifier.urihttps://hdl.handle.net/10657/3960
dc.language.isoeng
dc.rightsThe author of this work is the copyright owner. UH Libraries and the Texas Digital Library have their permission to store and provide access to this work. Further transmission, reproduction, or presentation of this work is prohibited except with permission of the author(s).
dc.subjectLupus nephritis
dc.subjectSLE
dc.subjectUrinary biomarkers
dc.subjectAptamers
dc.titleIdentification and Quantitation of Novel Urinary Biomarkers of Lupus Nephritis
dc.type.dcmiText
dc.type.genreThesis
local.embargo.lift2020-08-01
local.embargo.terms2020-08-01
thesis.degree.collegeCullen College of Engineering
thesis.degree.departmentBiomedical Engineering, Department of
thesis.degree.disciplineBiomedical Engineering
thesis.degree.grantorUniversity of Houston
thesis.degree.levelDoctoral
thesis.degree.nameDoctor of Philosophy

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