Assessment of Tissue Biomechanical Properties Using Ultrasound Elastography and Optical Coherence Elastography

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dc.contributor.advisorLarin, Kirill V.
dc.contributor.committeeMemberAglyamov, Salavat R.
dc.contributor.committeeMemberLiu, Jingfei
dc.contributor.committeeMemberWu, Tianfu
dc.contributor.committeeMemberSchultz, Jerome S.
dc.contributor.committeeMemberMayerich, David
dc.creatorRippy, Justin Randall
dc.creator.orcid0000-0001-5251-9400
dc.date.accessioned2023-05-26T16:02:02Z
dc.date.createdMay 2022
dc.date.issued2022-05-10
dc.date.updated2023-05-26T16:02:04Z
dc.description.abstractThis dissertation reports several significant contributions that further the field of elastography as a whole. Each chapter also represents a key step toward the realization of quantitative compression elastography (QCE). First, motion estimation algorithms were analyzed in chapter 2 to determine which algorithm allowed for the most accurate measurement of motion and subsequent elastic wave speed. This is significant for the entire field of elastography, as motion estimation algorithms are used regardless of choice of imaging modality or method. Following this, ultrasound shear wave elastography and transient optical coherence elastography were compared under similar conditions in chapter 3 to determine if they gave comparable results. This analysis proves that the results obtained from both modalities are comparable and that they can be used interchangeably. While this is important for the field of elastography, i.e., measurements taken with one can and should be compared to the other, it is absolutely crucial for the development of QCE. If the two methods cannot give comparable results, it follows that techniques used to obtain quantitative information from one cannot be used in the other. Chapter 4 contains the most significant contribution, which is the development of QCE. QCE is a simple, multi-modal, quantitative elastography technique that borrows the idea of a compliant stress sensor from optical coherence elastography and improves upon it by removing the need for calibration. Because strain imaging and wave excitation can be performed without moving the transducer, ultrasound has the unique ability to essentially calibrate the sensor in place during the act of compression. Furthermore, this allows for a more accurate measurement than is typically possible when using a compliant sensor because the exact sensor conditions can be known at the time of measurement instead of assumed from uniaxial compression testing. Overall, the contributions of this work serve to increase accuracy in elastographic measurements, further multimodal elastography, and serve as the genesis of quantitative compression elastography methods in ultrasound.
dc.description.departmentBiomedical Engineering, Department of
dc.format.digitalOriginborn digital
dc.format.mimetypeapplication/pdf
dc.identifier.citationPortions of this document appear in: Rippy, Justin R., Manmohan Singh, Salavat R. Aglyamov, and Kirill V. Larin. "Ultrasound shear wave elastography and transient optical coherence elastography: side-by-side comparison of repeatability and accuracy." IEEE open journal of engineering in medicine and biology 2 (2021): 179-186; and in: Manmohan, Singh, and Aglyamov Salavat. "Accuracy of Common Motion Estimators in Wave-Based Optical Coherence Elastography." Journal of Biomedical Photonics & Engineering 7, no. 4 (2021): 40303.
dc.identifier.urihttps://hdl.handle.net/10657/14279
dc.language.isoeng
dc.rightsThe author of this work is the copyright owner. UH Libraries and the Texas Digital Library have their permission to store and provide access to this work. UH Libraries has secured permission to reproduce any and all previously published materials contained in the work. Further transmission, reproduction, or presentation of this work is prohibited except with permission of the author(s).
dc.subjectOptical coherence elastography
dc.subjectUltrasound elastography
dc.subjectQuantitative compression elastography
dc.titleAssessment of Tissue Biomechanical Properties Using Ultrasound Elastography and Optical Coherence Elastography
dc.type.dcmiText
dc.type.genreThesis
dcterms.accessRightsThe full text of this item is not available at this time because the student has placed this item under an embargo for a period of time. The Libraries are not authorized to provide a copy of this work during the embargo period.
local.embargo.lift2024-05-01
local.embargo.terms2024-05-01
thesis.degree.collegeCullen College of Engineering
thesis.degree.departmentBiomedical Engineering, Department of
thesis.degree.disciplineBiomedical Engineering
thesis.degree.grantorUniversity of Houston
thesis.degree.levelDoctoral
thesis.degree.nameDoctor of Philosophy

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