Breast Cancer Treatment-Completion: Can an Integrative Medicine Center Play a Role?

Simple item page
dc.contributor.advisorNarendorf, Sarah C.
dc.contributor.committeeMemberTorres, Isabel
dc.contributor.committeeMemberCohen, Lorenzo
dc.creatorWagner, Richard W.
dc.creator.orcid0000-0002-5957-1743
dc.date.accessioned2021-08-26T19:24:50Z
dc.date.available2021-08-26T19:24:50Z
dc.date.createdMay 2021
dc.date.issued2021-05
dc.date.submittedMay 2021
dc.date.updated2021-08-26T19:24:52Z
dc.description.abstractIntroduction: The survival of women with breast cancer depends on treatment-completion. We explored factors that promote treatment-completion and reduce aromatase inhibitor (AI) medication switching. We evaluated the effect of any Integrative Medicine (IM) clinic use on those outcomes. Methods: Means, frequencies, modified Poisson regression analysis, and propensity score analysis were used to examine three samples of women with hormone receptor-positive breast cancer treated with taxane chemotherapy or hormone therapy between 1/1/2009-12/31/2019 at MD Anderson Cancer Center. Treatment-completion was defined as a relative dose-intensity(RDI) of ≥85% for chemotherapy, or ≥54 months with a hormone therapy prescription; AI switching was also assessed. Sample: There were 508, 3764, and 2253 women in the chemotherapy, hormone therapy, and AI switching samples, respectively. Results: We found that 53.1% of patients completed chemotherapy, 64.3% of patients completed hormone therapy, and 68.8% of patients took just one AI medication. Less pain (RR, 0.97; 95%CI, 0.95 to 0.98; p<0.001) and SF-12 PCS (RR 1.03; 95%CI: 1.02 to 1.05; p<0.001) were associated with increase probability of hormone therapy treatment-completion in bivariate analysis. Differences between IM clinic users and non-users were not statistically significant among the samples. Discussion: Many women did not complete treatment. Two quality-of-life measures were related to hormone therapy treatment-completion. Treatment-completion of IM clinic users were not different from non-users. Some predictors of treatment-completion are changeable and warrant a central focus during treatment. Future research should include more IM treatments (e.g., 8 acupuncture treatments) for the inclusion criteria.
dc.description.departmentSocial Work, Graduate College of
dc.format.digitalOriginborn digital
dc.format.mimetypeapplication/pdf
dc.identifier.urihttps://hdl.handle.net/10657/8109
dc.language.isoeng
dc.rightsThe author of this work is the copyright owner. UH Libraries and the Texas Digital Library have their permission to store and provide access to this work. Further transmission, reproduction, or presentation of this work is prohibited except with permission of the author(s).
dc.subjectBreast Cancer
dc.subjectTreatment-Completion
dc.subjectRelative Dose Intensity
dc.subjectIntegrative Medicine
dc.subjectPropensity Score
dc.titleBreast Cancer Treatment-Completion: Can an Integrative Medicine Center Play a Role?
dc.type.dcmiText
dc.type.genreThesis
thesis.degree.collegeGraduate College of Social Work
thesis.degree.departmentSocial Work, Graduate College of
thesis.degree.disciplineSocial Work
thesis.degree.grantorUniversity of Houston
thesis.degree.levelDoctoral
thesis.degree.nameDoctor of Philosophy

Files

Original bundle

Now showing 1 - 1 of 1
Thumbnail Image
Name:
WAGNER-DISSERTATION-2021.pdf
Size:
2.19 MB
Format:
Adobe Portable Document Format
Download

License bundle

Now showing 1 - 2 of 2
No Thumbnail Available
Name:
PROQUEST_LICENSE.txt
Size:
4.43 KB
Format:
Plain Text
Description:
Download
No Thumbnail Available
Name:
LICENSE.txt
Size:
1.81 KB
Format:
Plain Text
Description:
Download

Collections

Published ETD Collection