A Translational Animal Model Of Radiation-Induced Effects On Cognitive Functions: A Feasibility Study

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dc.contributor.advisorLeasure, J. Leigh
dc.contributor.committeeMemberHernandez, Arturo E.
dc.contributor.committeeMemberYoshida, Hanako
dc.creatorTrevino, Melissa 1985-
dc.date.accessioned2018-03-01T22:32:39Z
dc.date.available2018-03-01T22:32:39Z
dc.date.createdMay 2013
dc.date.issued2013-05
dc.date.submittedMay 2013
dc.date.updated2018-03-01T22:32:39Z
dc.description.abstractNeurocognitive late-effects are commonly reported among survivors of pediatric brain cancer. Radiation therapy has been linked to these neurocognitive deficits in attention, working memory, and processing speed. The current feasibility study was conducted in order to establish whether it is possible to model these deficits in the rodent. Using the 5-Choice Serial Reaction Time Task (5-CSRTT), prefrontal cognitive processes, which are reported to be among the most affected in the pediatric cancer population, can be assessed in the rodent. Irradiated and control animals were trained to perform the 5-CSRTT and tested at four separate time points. Irradiated animals showed significant impairments compared with control animals at 5, 7, and 12 months post-irradiation. These results show that deficits in prefrontal-mediated cognitive processes induced by radiation therapy can be successfully modeled in the rodent.
dc.description.departmentPsychology, Department of
dc.format.digitalOriginborn digital
dc.format.mimetypeapplication/pdf
dc.identifier.urihttp://hdl.handle.net/10657/2686
dc.language.isoeng
dc.rightsThe author of this work is the copyright owner. UH Libraries and the Texas Digital Library have their permission to store and provide access to this work. Further transmission, reproduction, or presentation of this work is prohibited except with permission of the author(s).
dc.subjectRadiation therapy
dc.subjectPediatric cancer
dc.subjectCognitive deficits
dc.subjectAttention
dc.subject5-choice serial reaction time task
dc.titleA Translational Animal Model Of Radiation-Induced Effects On Cognitive Functions: A Feasibility Study
dc.type.dcmiText
dc.type.genreThesis
thesis.degree.collegeCollege of Liberal Arts and Social Sciences
thesis.degree.departmentPsychology, Department of
thesis.degree.disciplinePsychology
thesis.degree.grantorUniversity of Houston
thesis.degree.levelMasters
thesis.degree.nameMaster of Arts

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