Chemiluminescent Detection of 1,5-Anhydroglucitol in Saliva for Diabetes Mellitus Screening

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dc.contributor.advisorWillson, Richard C.
dc.contributor.committeeMemberOrman, Mehmet A.
dc.contributor.committeeMemberRodrigues, Debora F.
dc.creatorHlavinka, Victoria M.
dc.date.accessioned2018-11-30T15:54:30Z
dc.date.available2018-11-30T15:54:30Z
dc.date.createdMay 2018
dc.date.issued2018-05
dc.date.submittedMay 2018
dc.date.updated2018-11-30T15:54:30Z
dc.description.abstractDiabetes mellitus is a severe, chronic disease that affects over 420 million people worldwide. The onset of complications due to diabetes can be delayed or even prevented when the disease is diagnosed early. However, it is estimated that nearly a quarter of all diabetes cases are undiagnosed. Screening in communities without adequate access to healthcare can drastically reduce the number of undiagnosed cases of diabetes in these areas. We have developed a chemiluminescence assay to quantify 1,5-anhydroglucitol (AHG), a glucose analog that falls in concentration during periods of hyperglycemia, in saliva for diabetes screening. We have demonstrated the ability of the assay to distinguish between healthy and diabetic individuals by testing 250 human samples (p < 0.0001). The accuracy of the assay determined by a receiver operating characteristic curve is 81%. The resultant study suggests that our assay can be used as a noninvasive tool to screen for diabetes.
dc.description.departmentChemical and Biomolecular Engineering, Department of
dc.format.digitalOriginborn digital
dc.format.mimetypeapplication/pdf
dc.identifier.urihttp://hdl.handle.net/10657/3442
dc.language.isoeng
dc.rightsThe author of this work is the copyright owner. UH Libraries and the Texas Digital Library have their permission to store and provide access to this work. Further transmission, reproduction, or presentation of this work is prohibited except with permission of the author(s).
dc.subjectChemiluminescence
dc.subject1,5-anhydroglucitol
dc.subjectDiabetes
dc.titleChemiluminescent Detection of 1,5-Anhydroglucitol in Saliva for Diabetes Mellitus Screening
dc.type.dcmiText
dc.type.genreThesis
local.embargo.lift2020-05-01
local.embargo.terms2020-05-01
thesis.degree.collegeCullen College of Engineering
thesis.degree.departmentChemical and Biomolecular Engineering, Department of
thesis.degree.disciplineChemical Engineering
thesis.degree.grantorUniversity of Houston
thesis.degree.levelMasters
thesis.degree.nameMaster of Science

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