Biomechanical Characterization of Crystalline Lens by Optical Coherence Elastography

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dc.contributor.advisorLarin, Kirill V.
dc.contributor.committeeMemberAglyamov, Salavat R.
dc.contributor.committeeMemberSchultz, Jerome S.
dc.contributor.committeeMemberZhang, Yingchun
dc.contributor.committeeMemberManns, Fabrice
dc.creatorZhang, Hongqiu
dc.creator.orcid0000-0002-8909-6429
dc.date.accessioned2022-06-17T22:51:58Z
dc.date.createdDecember 2021
dc.date.issued2021-12
dc.date.submittedDecember 2021
dc.date.updated2022-06-17T22:51:59Z
dc.description.abstractThis dissertation reports on the application of optical coherence tomography (OCT) based elastography technique to assess the biomechanical properties of crystalline lens tissue noninvasively quantitatively. This work is summarized in four sections: 1) Assessing the Effects of Storage Medium on the Biomechanical Properties of Porcine Lens with Optical Coherence Elastography; 2) Optical Coherence Elastography of Cold Cataract in Porcine Lens; 3) The Mechanical Properties of Oxidative Cataract and the Potential Medical Treatment Measured by Optical Coherence Elastography; 4) Age-Related Changes in Rabbit Lens Viscoelasticity by Surface Wave Dispersion Analysis. These methods and applications are demonstrated with experiments on both tissue-mimicking phantoms (gelatin and agar) and lens (porcine and rabbit) ex vivo and in situ under different conditions (medium preservation, cold cataract, oxidative cataract, aging). This dissertation represents the frontier and emerging research area of noninvasive optical coherence elastography. It is expected to contribute to the field of quantitative biomechanical assessment with research and clinical-based applications.
dc.description.departmentBiomedical Engineering, Department of
dc.format.digitalOriginborn digital
dc.format.mimetypeapplication/pdf
dc.identifier.citationPortions of this document appear in: Zhang, H., Wu, C., Singh, M., Nair, A., Aglyamov, S. R., & Larin, K. V. (2019). Optical coherence elastography of cold cataract in porcine lens. In Journal of biomedical optics, 24(3), 036004; and in: Zhang, H., Singh, M., Nair, A., Larin, K. V., & Aglyamov, S. R. (2021, June). Elasticity Changes in the Crystalline Lens during Oxidative Damage and the Antioxidant Effect of Alpha-Lipoic Acid Measured by Optical Coherence Elastography. In Photonics (Vol. 8, No. 6, p. 207); and in: Zhang, H., Singh, M., Zvietcovich, F., Larin, K. V., & Aglyamov, S. R. (2022, January). Age-Related Changes in the Viscoelasticity of Rabbit Lens Characterized by Surface Wave Dispersion Analysis. In Quantum Electronics (Accepted).
dc.identifier.urihttps://hdl.handle.net/10657/9285
dc.language.isoeng
dc.rightsThe author of this work is the copyright owner. UH Libraries and the Texas Digital Library have their permission to store and provide access to this work. UH Libraries has secured permission to reproduce any and all previously published materials contained in the work. Further transmission, reproduction, or presentation of this work is prohibited except with permission of the author(s).
dc.subjectCrystalline Lens
dc.subjectOptical Coherence Elastography
dc.titleBiomechanical Characterization of Crystalline Lens by Optical Coherence Elastography
dc.type.dcmiText
dc.type.genreThesis
dcterms.accessRightsThe full text of this item is not available at this time because the student has placed this item under an embargo for a period of time. The Libraries are not authorized to provide a copy of this work during the embargo period.
local.embargo.lift2023-12-01
local.embargo.terms2023-12-01
thesis.degree.collegeCullen College of Engineering
thesis.degree.departmentBiomedical Engineering, Department of
thesis.degree.disciplineBiomedical Engineering
thesis.degree.grantorUniversity of Houston
thesis.degree.levelDoctoral
thesis.degree.nameDoctor of Philosophy

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