Part I: Applying The Boger A-Helix Mimetic Motif to Potentially Modulate Beclin-1 Mediated Protein-Protein Interactions Relating to Autophagic Flux for Oncological Purposes. Part II: Utilizing Peptidomimetics to Target The 5-HT2CR Through its Interaction with the Protein and Tumor Suppressor Phosphatase and Tensin Homologue (PTEN).

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dc.contributor.advisorGilbertson, Scott R.
dc.contributor.committeeMemberCuny, Gregory D.
dc.contributor.committeeMemberDo, Loi H.
dc.contributor.committeeMemberMay, Jeremy A.
dc.contributor.committeeMemberTeets, Thomas S.
dc.creatorHooson, James Frederick
dc.creator.orcid0000-0003-2914-4713
dc.date.accessioned2022-06-15T22:43:38Z
dc.date.createdDecember 2021
dc.date.issued2021-12
dc.date.submittedDecember 2021
dc.date.updated2022-06-15T22:43:39Z
dc.description.abstractBeclin-1 is a protein required for autophagosome formation; thus, it is an essential protein regarding macroautophagy. The Kritzer group previously designed the DD5-o peptide to induce autophagy. The DD5-o peptide shows a helical structure in solution. In the last 20 years, there has been a lot of synthetic progress in developing non-peptide α-helix mimetics. We applied the Boger α-helix mimic to target one-helical-face of the protein Beclin-1 for potential modulation of autophagic flux for prospective use in oncology. We have synthesized a variety of compounds, and they have been sent to our collaborators for biological assays to be performed. The serotonin 2C receptor has been implicated in a variety of psychiatric disorders. Previously, a peptidomimetic was found to disrupt the association between the serotonin 2C receptor and the Phosphatase and Tensin Homologue (PTEN). This disruption enhances serotonin 2C receptor downstream signaling and potentiates serotonin 2C receptor agonists. We synthesized a variety of analogues of the peptidomimetic, and these analogues have been sent to our collaborators for biological assays to be performed. We also attempted new synthetic routes to the bioactive peptidomimetic.
dc.description.departmentChemistry, Department of
dc.format.digitalOriginborn digital
dc.format.mimetypeapplication/pdf
dc.identifier.urihttps://hdl.handle.net/10657/9199
dc.language.isoeng
dc.rightsThe author of this work is the copyright owner. UH Libraries and the Texas Digital Library have their permission to store and provide access to this work. Further transmission, reproduction, or presentation of this work is prohibited except with permission of the author(s).
dc.subjectBeclin-1
dc.subjecthelical
dc.subjectα-helix
dc.subjectα-helix mimics
dc.subjectα-helix mimetics
dc.subjectone-helical-face
dc.subjectserotonin 2C receptor
dc.subjectPhosphatase and Tensin Homologue
dc.subjectPTEN
dc.subjectpeptidomimetic
dc.subjectβ-Proline
dc.subject(S)-β-Proline
dc.subject(R)-β-Proline
dc.titlePart I: Applying The Boger A-Helix Mimetic Motif to Potentially Modulate Beclin-1 Mediated Protein-Protein Interactions Relating to Autophagic Flux for Oncological Purposes. Part II: Utilizing Peptidomimetics to Target The 5-HT2CR Through its Interaction with the Protein and Tumor Suppressor Phosphatase and Tensin Homologue (PTEN).
dc.type.dcmiText
dc.type.genreThesis
dcterms.accessRightsThe full text of this item is not available at this time because the student has placed this item under an embargo for a period of time. The Libraries are not authorized to provide a copy of this work during the embargo period.
local.embargo.lift2023-12-01
local.embargo.terms2023-12-01
thesis.degree.collegeCollege of Natural Sciences and Mathematics
thesis.degree.departmentChemistry, Department of
thesis.degree.disciplineChemistry
thesis.degree.grantorUniversity of Houston
thesis.degree.levelDoctoral
thesis.degree.nameDoctor of Philosophy

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