Sensory Gating Analysis in Individuals with Copy Number Variants of CHRNA7

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dc.contributor.advisorJansen, Ben H.
dc.contributor.committeeMemberHiscock, Merrill
dc.contributor.committeeMemberOgmen, Haluk
dc.contributor.committeeMemberSchaaf, Christian Patrick
dc.creatorKagalwala, Hamza
dc.date.accessioned2018-03-05T20:23:17Z
dc.date.available2018-03-05T20:23:17Z
dc.date.createdAugust 2014
dc.date.issued2014-08
dc.date.submittedAugust 2014
dc.date.updated2018-03-05T20:23:17Z
dc.description.abstractSensory gating, the brain’s ability to suppress irrelevant stimuli, was studied in 15 subjects with CHRNA7 gene deletions, 16 with gene duplications, and 28 of their siblings. Pairs of brief tones were repeatedly presented and the brain’s responses to the first (S1) and second (S2) tone in each pair were recorded during baseline in all subjects, and after administration of a placebo and actual medication, respectively in the gene abnormality groups. The amplitude, latency and area under the curve were measured for the P50, N100 and P200 component. Siblings had smaller P200 amplitudes for S1 than patients, but no gating differences were observed. The P50 amplitude for S2 was smaller after medication than at baseline, and the corresponding gating ratio approached significance. In conclusion, subjects with CHRNA7 gene abnormalities and their siblings have similar gating ratios, but medication tends to reduce the P50 gating deficit.
dc.description.departmentElectrical and Computer Engineering, Department of
dc.format.digitalOriginborn digital
dc.format.mimetypeapplication/pdf
dc.identifier.urihttp://hdl.handle.net/10657/2805
dc.language.isoeng
dc.rightsThe author of this work is the copyright owner. UH Libraries and the Texas Digital Library have their permission to store and provide access to this work. Further transmission, reproduction, or presentation of this work is prohibited except with permission of the author(s).
dc.subjectEEG
dc.subjectSensory gating
dc.subjectSensory neuroscience
dc.subjectCHRNA7
dc.titleSensory Gating Analysis in Individuals with Copy Number Variants of CHRNA7
dc.type.dcmiText
dc.type.genreThesis
thesis.degree.collegeCullen College of Engineering
thesis.degree.departmentElectrical and Computer Engineering, Department of
thesis.degree.disciplineElectrical Engineering
thesis.degree.grantorUniversity of Houston
thesis.degree.levelMasters
thesis.degree.nameMaster of Science in Electrical Engineering

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