Development of a Blood Shear Stress Device using Numerical and Experimental methods

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dc.contributor.advisorMetcalfe, Ralph W.
dc.contributor.committeeMemberJoshi, Shailendra P.
dc.contributor.committeeMemberQuaini, Annalisa
dc.creatorKarnik, Shweta
dc.date.accessioned2020-06-02T04:15:51Z
dc.date.createdMay 2020
dc.date.issued2020-05
dc.date.submittedMay 2020
dc.date.updated2020-06-02T04:15:51Z
dc.description.abstractLeft Ventricular Assist Devices (LVADs) are mechanical pumps used to treat heart failure, which is the cause of 6.2 million deaths in the United States every year. Despite clinical success, the capability of LVADs to operate successfully without causing blood damage remains a challenge. Due to high fluid stresses for prolonged period, the circulatory components of a LVAD tend to cause mechanical destruction of red blood cells leading to the release of hemoglobin into the bloodstream, termed as hemolysis. We have developed a Blood Shear Stress Device (BSSD) for LVAD component testing which will aid in identifying the amount of blood damage caused and its source. This device will enable individual component analysis thereby improving LVAD design while simultaneously reducing development time and cost. The BSSD consists of an active and passive magnetic levitation system for the brushless DC (BLDC) motor and uses a large gap between the BLDC motor components as a blood flow region for the component testing of LVADs. The passive magnetic levitation system is comprised of two concentric permanent magnet bearings used to stabilize the BLDC motor radially. The development process of this device involved magnetic modelling using numerical and experimental methods to identify the dimensions of the BSSD components to eradicate the blood damage caused by the circulatory components. The proposed device design has been evaluated using computational fluid dynamics analysis for the blood damage caused due to the circulatory components of the BSSD by measuring the fluid shear stresses and their exposure time on the blood.
dc.description.departmentMechanical Engineering, Department of
dc.format.digitalOriginborn digital
dc.format.mimetypeapplication/pdf
dc.identifier.urihttps://hdl.handle.net/10657/6589
dc.language.isoeng
dc.rightsThe author of this work is the copyright owner. UH Libraries and the Texas Digital Library have their permission to store and provide access to this work. Further transmission, reproduction, or presentation of this work is prohibited except with permission of the author(s).
dc.subjectLVADs, Hemolysis, Magnetic Levitation, CFD
dc.titleDevelopment of a Blood Shear Stress Device using Numerical and Experimental methods
dc.type.dcmiText
dc.type.genreThesis
local.embargo.lift2022-05-01
local.embargo.terms2022-05-01
thesis.degree.collegeCullen College of Engineering
thesis.degree.departmentMechanical Engineering, Department of
thesis.degree.disciplineMechanical Engineering
thesis.degree.grantorUniversity of Houston
thesis.degree.levelMasters
thesis.degree.nameMaster of Science in Mechanical Engineering

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