Preparation and Characterization of Hydrogel-Core Liposomes for Drug Delivery Applications

Simple item page
dc.contributor.advisorMajd, Sheereen
dc.contributor.committeeMemberAbidian, Mohammad Reza
dc.contributor.committeeMemberWu, Tianfu
dc.creatorFarhadi, Hanieh
dc.date.accessioned2020-01-07T00:40:59Z
dc.date.createdMay 2019
dc.date.issued2019-05
dc.date.submittedMay 2019
dc.date.updated2020-01-07T00:41:01Z
dc.description.abstractLiposomes are amongst the most effective delivery vehicles developed to date. Despite many advantages including biocompatibility, biodegradability, and the ability to carry both hydrophilic and lipophilic compounds, liposomes suffer from low physical stability and controlled drug release. Inclusion of a polymeric scaffold within the core of liposomes can effectively address this limitation. Given the versatility of poly(ethylene glycol) (PEG) hydrogels, these polymers are particularly attractive for the use in liposomal core. Towards development of robust liposomal delivery systems, here we aim to develop a simple and reliable technique for the fabrication of liposomes with hydrogel cores. We assess the resultant nanoparticles (NPs) using scanning electron microscopy and dynamic light scattering and demonstrate that the presented approach can successfully produce gel-liposome nanoparticles with spherical shape and 100-300 nm size. These nanoparticles are further evaluated for colloidal stability in physiological solution. Moreover, we demonstrate the versatility of this method by studying the effect of changing (A) the membrane composition in liposomes, (B) the polymer and cross-linker concentration in liposomal core, and (C) the polymer content on the formation of hydrogel-core liposomes.
dc.description.departmentBiomedical Engineering, Department of
dc.format.digitalOriginborn digital
dc.format.mimetypeapplication/pdf
dc.identifier.urihttps://hdl.handle.net/10657/5811
dc.language.isoeng
dc.rightsThe author of this work is the copyright owner. UH Libraries and the Texas Digital Library have their permission to store and provide access to this work. Further transmission, reproduction, or presentation of this work is prohibited except with permission of the author(s).
dc.subjectLiposomes
dc.subjectLipids
dc.subjectDrug delivery
dc.subjectNanoparticles
dc.subjectNanogel
dc.subjectNanomedicine
dc.subjectPhospholipids
dc.subjectHydrogel
dc.subjectPoly(ethylene glycol) (PEG)
dc.titlePreparation and Characterization of Hydrogel-Core Liposomes for Drug Delivery Applications
dc.type.dcmiText
dc.type.genreThesis
local.embargo.lift2021-05-01
local.embargo.terms2021-05-01
thesis.degree.collegeCullen College of Engineering
thesis.degree.departmentBiomedical Engineering, Department of
thesis.degree.disciplineBiomedical Engineering
thesis.degree.grantorUniversity of Houston
thesis.degree.levelMasters
thesis.degree.nameMaster of Science in Biomedical Engineering

Files

Original bundle

Now showing 1 - 1 of 1
Thumbnail Image
Name:
FARHADI-THESIS-2019.pdf
Size:
2.69 MB
Format:
Adobe Portable Document Format
Download

License bundle

Now showing 1 - 2 of 2
No Thumbnail Available
Name:
PROQUEST_LICENSE.txt
Size:
4.43 KB
Format:
Plain Text
Description:
Download
No Thumbnail Available
Name:
LICENSE.txt
Size:
1.81 KB
Format:
Plain Text
Description:
Download

Collections

Published ETD Collection