Growth and Nucleation Modifiers of Calcium Oxalate Mineralization

Simple item page
dc.contributor.advisorRimer, Jeffrey D.
dc.contributor.committeeMemberVekilov, Peter G.
dc.contributor.committeeMemberVaradarajan, Navin
dc.contributor.committeeMemberPalmer, Jeremy C.
dc.contributor.committeeMemberMiljanić, Ognjen Š.
dc.contributor.committeeMemberBrgoch, Jakoah
dc.creatorAlamani, Bryan Gencianeo
dc.creator.orcid0000-0002-6063-8108
dc.date.accessioned2019-09-10T13:37:06Z
dc.date.createdDecember 2018
dc.date.issued2018-12
dc.date.submittedDecember 2018
dc.date.updated2019-09-10T13:37:07Z
dc.description.abstractCrystallization is a ubiquitous process essential in chemical, biological, physical and geological phenomena. The kinetics and thermodynamics facilitating crystallization are important metrics that allow understanding of the underlying mechanisms in determining the structure and property of the crystal. Insights from such fundamental studies of growth establish rules or heuristics useful to tune the structure and property of the crystals to transition into functional materials that find applications in energy, environment, and health. This dissertation focuses on the mineralization of calcium oxalate monohydrate (COM), the most common constituent of human kidney stones, and the mechanisms by which various modifiers alter the rate of COM formation with concomitant changes in crystal properties (e.g., size and shape). Specifically, we investigated modifiers that can inhibit nucleation and growth of COM, which can be potential candidates for new therapeutics of pathological calcification in humans. In certain cases, promoters of growth and intergrowth formation have been identified, which can be insightful in understanding COM formation in plants. We employed macroscopic and molecular scale approaches to investigate the influence of divalent ions (Zn2+, Sr2+, and Mg2+) and polyphosphates (hexametaphosphate, linear tripolyphosphate, and cyclic trimetaphosphate) on COM mineralization. These ions and molecules interact with the crystal through mechanisms dominated by thermodynamic and/or kinetic processes. We examined the impact of these modifiers on the morphology and kinetics of COM crystallization. In these studies, we have uncovered unique modes of action for several modifiers where ions (e.g., Zn2+ and Sr2+) can have dual modes of action in modulating COM crystallization. Cyclic polyphosphates (HMP), on the other hand, can be effective nucleation inhibitors, but only moderately effective growth inhibitors, while linear polyphosphates (LTPP) are only effective growth inhibitors. Some modifiers (e.g., Mg2+ and CTMP) do not impact the overall crystallization rate, which cannot be easily explained from our experiments. Overall, our understanding of modifier-crystal interactions that mediate COM crystallization can be useful in obtaining guidelines or heuristics in designing processes to regulate materials assembly. Specifically, the combination of bulk and interfacial approaches in deciphering modifier-crystal interactions may find use in screening preventative drug candidates that are capable of inhibiting pathological calcification.
dc.description.departmentChemical and Biomolecular Engineering, Department of
dc.format.digitalOriginborn digital
dc.format.mimetypeapplication/pdf
dc.identifier.urihttps://hdl.handle.net/10657/4385
dc.language.isoeng
dc.rightsThe author of this work is the copyright owner. UH Libraries and the Texas Digital Library have their permission to store and provide access to this work. Further transmission, reproduction, or presentation of this work is prohibited except with permission of the author(s).
dc.subjectCrystallization
dc.subjectModifiers
dc.titleGrowth and Nucleation Modifiers of Calcium Oxalate Mineralization
dc.type.dcmiText
dc.type.genreThesis
local.embargo.lift2020-12-01
local.embargo.terms2020-12-01
thesis.degree.collegeCullen College of Engineering
thesis.degree.departmentChemical and Biomolecular Engineering, Department of
thesis.degree.disciplineChemical Engineering
thesis.degree.grantorUniversity of Houston
thesis.degree.levelDoctoral
thesis.degree.nameDoctor of Philosophy

Files

Original bundle

Now showing 1 - 1 of 1
No Thumbnail Available
Name:
ALAMANI-DISSERTATION-2018.pdf
Size:
3.75 MB
Format:
Adobe Portable Document Format
Download

License bundle

Now showing 1 - 2 of 2
No Thumbnail Available
Name:
PROQUEST_LICENSE.txt
Size:
4.43 KB
Format:
Plain Text
Description:
Download
No Thumbnail Available
Name:
LICENSE.txt
Size:
1.81 KB
Format:
Plain Text
Description:
Download

Collections

Published ETD Collection