Assessing Tissue Biomechanical Properties with Noncontact Dynamic Optical Coherence Elastography

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dc.contributor.advisorLarin, Kirill V.
dc.contributor.committeeMemberAkay, Metin
dc.contributor.committeeMemberTwa, Michael D.
dc.contributor.committeeMemberGifford, Howard C.
dc.contributor.committeeMemberMayerich, David
dc.creatorSingh, Manmohan
dc.date.accessioned2018-12-03T14:36:11Z
dc.date.available2018-12-03T14:36:11Z
dc.date.createdMay 2018
dc.date.issued2018-05
dc.date.submittedMay 2018
dc.date.updated2018-12-03T14:36:11Z
dc.description.abstractThis dissertation reports the development of noncontact techniques to quantify the biomechanical properties of various tissues utilizing optical coherence elastography. These techniques are critical for screening, detection, and monitoring of disease onset and progression as well as evaluating the effectiveness of various therapeutic procedures. The dissertation is divided into two major sections: 1) analyzing the localized dynamic deformation and 2) analyzing elastic wave propagation to quantify tissue biomechanical properties. Each of these sections is further divided. The localized dynamic tissue deformation analysis section has two sub-sections: a) real-time visual feedback and biomechanical assessment of dermal filler injections and b) evaluating the changes in local cardiac biomechanical properties after myocardial infarction. The elastic wave propagation analysis section has seven sub-sections: a) evaluating the changes in corneal biomechanical properties due to riboflavin/UV-A corneal collagen cross-linking, b) comparing the changes in corneal biomechanical properties induced by riboflavin/UV-A and rose-bengal/green light collagen cross-linking, c) quantifying the effects of tissue hydration on the stiffness of the cornea, d) assessing the elastic anisotropy of the cornea as a function of intraocular pressure, e) evaluating the changes in cardiac elastic anisotropy after myocardial infarction, f) development of an ultra-fast, single-shot, elastography technique, and g) development of a noncontact technique ca pable of assessing corneal geometry, eye-globe intraocular pressure, and corneal stiffness with a single instrument. Finally, the spatio-temporal properties of air-pulse induced displacement were characterized, and the repeatability and sensitivity of the OCE techniques described in this dissertation were compared to the “gold standard” of mechanical testing. The contributions of this work are crucial steps for the further development and clinical application of rapid, accurate, robust, and safe techniques capable of evaluating tissue biomechanical properties for early detection and monitoring of diseases.
dc.description.departmentBiomedical Engineering, Department of
dc.format.digitalOriginborn digital
dc.format.mimetypeapplication/pdf
dc.identifier.urihttp://hdl.handle.net/10657/3590
dc.language.isoeng
dc.rightsThe author of this work is the copyright owner. UH Libraries and the Texas Digital Library have their permission to store and provide access to this work. Further transmission, reproduction, or presentation of this work is prohibited except with permission of the author(s).
dc.subjectOptical coherence tomography (OCT)
dc.subjectOptical coherence elastography
dc.subjectVision sciences
dc.subjectBiomechanical properties
dc.subjectViscoelasticity
dc.titleAssessing Tissue Biomechanical Properties with Noncontact Dynamic Optical Coherence Elastography
dc.type.dcmiText
dc.type.genreThesis
local.embargo.lift2020-05-01
local.embargo.terms2020-05-01
thesis.degree.collegeCullen College of Engineering
thesis.degree.departmentBiomedical Engineering, Department of
thesis.degree.disciplineBiomedical Engineering
thesis.degree.grantorUniversity of Houston
thesis.degree.levelDoctoral
thesis.degree.nameDoctor of Philosophy

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