Mirror Neurons are Modulated by Reward Expectation and Grip Force in the Sensorimotor Cortices (S1, M1, PMd, PMv)

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dc.contributor.advisorFrancis, Joseph T.
dc.contributor.committeeMemberInce, Nuri F.
dc.contributor.committeeMemberZhang, Yingchun
dc.contributor.committeeMemberFrancis, David J.
dc.contributor.committeeMemberFaghih, Rose T.
dc.creatorAtique, MD Moin Uddin
dc.date.accessioned2021-10-06T15:51:41Z
dc.date.createdMay 2021
dc.date.issued2021-05
dc.date.submittedMay 2021
dc.date.updated2021-10-06T15:51:44Z
dc.description.abstractMirror Neurons (MN) respond similarly when primates make, or observe, grasping movements. Recent work indicates that reward expectation influences M1 during manual, observational, and Brain Machine Interface (BMI) reaching movements. Previous work showed MN are modulated by subjective value. Here we expand on the above work utilizing two non-human primates (NHPs), one male Macaca Radiata (NHP S) and one female Macaca Mulatta (NHP P), that were trained to perform a cued reward level isometric grip force task, where the NHPs had to apply visually cued grip force to move and transport a virtual object. We found a population of (S1, M1, PMd, PMv) units that significantly represented grip force during manual and observational trials. We found the neural representation of visually cued force was similar during observational trials and manual trials for the same units, however, the representation was weaker during observational trials. Comparing changes in neural time lags between manual and observational tasks indicated that a subpopulation fit the standard MN definition of observational neural activity lagging the visual information. Neural activity in (S1, M1, PMd, PMv) significantly represented force and reward expectation. In summary, we present results indicating that sensorimotor cortices have MN for visually cued force and value.
dc.description.departmentBiomedical Engineering, Department of
dc.format.digitalOriginborn digital
dc.format.mimetypeapplication/pdf
dc.identifier.urihttps://hdl.handle.net/10657/8298
dc.language.isoeng
dc.rightsThe author of this work is the copyright owner. UH Libraries and the Texas Digital Library have their permission to store and provide access to this work. Further transmission, reproduction, or presentation of this work is prohibited except with permission of the author(s).
dc.subjectMirror Neuron
dc.subjectGrip Force Task
dc.subjectNeuroscience
dc.subjectReward Expectation
dc.titleMirror Neurons are Modulated by Reward Expectation and Grip Force in the Sensorimotor Cortices (S1, M1, PMd, PMv)
dc.type.dcmiText
dc.type.genreThesis
local.embargo.lift2023-05-01
local.embargo.terms2023-05-01
thesis.degree.collegeCullen College of Engineering
thesis.degree.departmentBiomedical Engineering, Department of
thesis.degree.disciplineBiomedical Engineering
thesis.degree.grantorUniversity of Houston
thesis.degree.levelDoctoral
thesis.degree.nameDoctor of Philosophy

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