Inhibition of Calcium Oxalate Monohydrate Crystallization Using Organic Growth Modifiers

Simple item page
dc.contributor.advisorRimer, Jeffrey D.
dc.contributor.committeeMemberRobertson, Megan L.
dc.contributor.committeeMemberMiljanić, Ognjen Š.
dc.creatorChung, Jihae
dc.date.accessioned2015-08-24T02:09:30Z
dc.date.available2015-08-24T02:09:30Z
dc.date.createdMay 2013
dc.date.issued2013-05
dc.date.updated2015-08-24T02:09:30Z
dc.description.abstractInhibition of calcium oxalate monohydrate (COM), the most common component in human kidney stone diseases, was investigated using various structural derivatives of citrate, a known inhibitor of COM crystallization. Bulk crystallization studies revealed the specific binding of modifiers to COM crystal surfaces. Kinetic studies were performed to quantify both the efficacy and potency of growth inhibitors. These studies demonstrated that increased number of hydroxyl and carboxyl groups play a crucial role in interacting with specific COM crystal surface. Designing effective inhibitors require a fundamental understanding of modifier-crystal interactions at the molecular level. Consequently, we have used in situ AFM to observe the COM surface growth in the absence and in the presence of a growth inhibitor. Results obtained in this study may serve as a general platform to investigate the molecular recognition between modifiers and COM crystal surfaces as a step towards designing preventative drugs for kidney stone disease.
dc.description.departmentChemical and Biomolecular Engineering, Department of
dc.format.digitalOriginborn digital
dc.format.mimetypeapplication/pdf
dc.identifier.urihttp://hdl.handle.net/10657/1028
dc.language.isoeng
dc.rightsThe author of this work is the copyright owner. UH Libraries and the Texas Digital Library have their permission to store and provide access to this work. Further transmission, reproduction, or presentation of this work is prohibited except with permission of the author(s).
dc.subjectCrystallization
dc.subjectKidney stone
dc.subjectRenal health
dc.subjectKidney health
dc.subjectInhibition
dc.subject.lcshChemical engineering
dc.titleInhibition of Calcium Oxalate Monohydrate Crystallization Using Organic Growth Modifiers
dc.type.dcmiText
dc.type.genreThesis
thesis.degree.collegeCullen College of Engineering
thesis.degree.departmentChemical and Biomolecular Engineering, Department of
thesis.degree.disciplineChemical Engineering
thesis.degree.grantorUniversity of Houston
thesis.degree.levelMasters
thesis.degree.nameMaster of Science

Files

Original bundle

Now showing 1 - 1 of 1
Thumbnail Image
Name:
CHUNG-THESIS-2013.pdf
Size:
1.71 MB
Format:
Adobe Portable Document Format
Download

License bundle

Now showing 1 - 1 of 1
No Thumbnail Available
Name:
LICENSE.txt
Size:
1.84 KB
Format:
Plain Text
Description:
Download

Collections

Published ETD Collection