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dc.contributor.advisorOstilla-Mónico, Rodolfo
dc.contributor.advisorAlba, Kamran
dc.creatorMitra, Harsa
dc.date.accessioned2020-06-07T03:36:41Z
dc.date.createdMay 2020
dc.date.issued2020-05
dc.date.submittedMay 2020
dc.identifier.urihttps://hdl.handle.net/10657/6737
dc.description.abstractThis Master’s thesis work is composed of two research categories. The first part seeks to develop a better understanding of the rheological properties of platelet-rich plasma (PRP), a blood-derived product used as a therapy for osteoarthritis and tendon injuries and the second part aims at evaluation of the flow-induced vibration (FIV) within a subsea choke valve. Blood-derived products, particularly PRP, have received increased attention in the past several years due to their great potential as a therapy for osteoarthritis and tendon injuries. Therefore, characterizing the mechanical properties of PRP becomes important to better understand its therapeutic efficacy. Rheological characterization of PRP provides further insight into its mechanism of action. Flow-sweep, Small Amplitude Oscillatory Shear (SAOS), Large Amplitude Oscillatory Shear (LAOS), and thixotropy tests have been performed at room and physiological temperatures to characterize the non-Newtonian properties of PRP samples. Flow-sweep tests reveal shear-thinning behavior (also observed in LAOS experiments), with higher apparent viscosity observed at temperature. Rheological models such as Carreau, Casson, power-law, and Herschel-Bulkley have been fitted to the flow-sweep data with the latter showing the closest agreement. The calculated boundaries of low/high-shear rates in flow-sweep tests as well as minimum-torque, sample-inertia, and instrument-inertia limits in SAOS frequency-sweep experiments are correspondingly provided for accurate interpretation of the results. Although, the window of interpretable SAOS results is found to be narrow. Furthermore, the non-linear and transient viscoelasticity is quantified with the help of the LAOS tests. The thixotropic behavior of PRP solutions is further quantified through the peak-hold test, and further compared against the results of whole blood previously published in the literature. Part two of the thesis investigates a wellhead choke valve, a type of control valve, which is mostly used to control the flow and pressure of fluids from a reservoir in an oil and gas production. A numerical study is performed using STAR-CCM+ software to study and visualize the complex physics of the compressible flow in question. Our study is carried out on a subsea choke valve model obtained from Master Flo Valve (USA) Inc., FIV investigation on dominant frequency modes within the flow has been conducted using fast-Fourier transform (FFT). The dominant frequency is then compared against the experimental natural frequency of vibration of the valve assembly to assess the risk of resonance and mechanical failure. To complement the FFT analysis, the Mach number, pressure, and temperature contours have been presented on three orthogonal planes within the valve.
dc.format.mimetypeapplication/pdf
dc.language.isoen
dc.rightsThe author of this work is the copyright owner. UH Libraries and the Texas Digital Library have their permission to store and provide access to this work. Further transmission, reproduction, or presentation of this work is prohibited except with permission of the author(s).
dc.subjectRheology
dc.subjectplatelet-rich plasma
dc.subjectcfd
dc.subjectflow-induced vibration
dc.subjectsubsea choke valves
dc.subjectarthritis
dc.subjectstar-ccm+
dc.subjectfluid dynamics, oil and gas.
dc.titleBiorheology (Part I) & Numerical Investigation of Flow-Induced Vibration (Part II)
dc.date.updated2020-06-07T03:36:41Z
dc.type.genreThesis
thesis.degree.nameMaster of Science
thesis.degree.levelMasters
thesis.degree.disciplineMechanical Engineering
thesis.degree.grantorUniversity of Houston
thesis.degree.departmentMechanical Engineering, Department of
dc.contributor.committeeMemberMetcalfe, Ralph W.
dc.contributor.committeeMemberKoeck, Frank
dc.creator.orcid0000-0002-0730-6104
local.embargo.terms2022-05-01
local.embargo.lift2022-05-01
dcterms.accessRightsThe full text of this item is not available at this time because the student has placed this item under an embargo for a period of time. The Libraries are not authorized to provide a copy of this work during the embargo period.
dc.type.dcmiText
dc.format.digitalOriginborn digital
dc.description.departmentMechanical Engineering, Department of
thesis.degree.collegeCullen College of Engineering


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