Sensors and System Integration for Magnetic Resonance Image (MRI)-Guided and Robot-Assisted Interventions

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AN-DISSERTATION-2016.pdf (5.48 MB)

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2016-05

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Abstract

Demand for magnetic resonance image (MRI)-guided interventions and robot-assisted surgeries continues to increase in the field of medical robotics. MRI-guided interventions provide pre-/intra-operative MR images and intraoperative manipulations. Robot-assisted surgeries guarantee higher safety and greater dexterity inside the patient’s body. Integration of MRI-guided and robot-assisted intervention techniques bring better precision, increased dexterity, and improved 3D visualization for surgery planning and real-time MR guidance. Despite the significant benefits of these techniques, potential challenges still remain: (i) for localization and tracking of MR-compatible manipulators using MR-visible markers, (ii) for 3D visualization of catheters and blood vessels in planning and guidance of interventional devices, (iii) for complementary characterization of human tissues and organs using multimodality imaging approaches, (iv) for higher flexibility and accessibility to overcome lack of navigation and limited workspace inside the human body and the MRI scanner. This dissertation describes the development of several enabling technologies for the MRI-guided and robot-assisted interventions. The specific technologies encompassed are: (i) an inductively coupled radio frequency (ICRF) coils that are optically tuned and detuned by the control of an MR-compatible manipulator for accurate localization and fast tracking, (ii) a novel method for 3D reconstruction of tubular structures such as catheters and blood vessels from three orthogonal MR projection images, (iii) an MR-compatible optical encoder for position feedback of the MR-compatible manipulators, (iv) a manipulator-mounted magnetic resonance spectroscopy (MRS) / light induced fluorescence (LIF) probe for multimodality bioimaging and biosensing applications, (v) an MR-compatible dexterous robotic manipulator for providing higher flexibility and accessibility, (vi) and the integration of the above mentioned techniques for the MRI-guided and robot-assisted interventions.

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MRI-Guided, Robot-Assisted, MRI Compatibility, Biosensors, MR-Compatible Manipulator

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Portions of this document have appeared in: An, Junmo, Xin Liu, Mahmut Unan, Eftychios G. Christoforou, Andrew G. Webb, and Nikolaos V. Tsekos. "Tracking of MRI Interventional Devices with Computer-Controlled Detunable Markers." In XIV Mediterranean Conference on Medical and Biological Engineering and Computing 2016, pp. 663-667. Springer, Cham, 2016. DOI: 10.1007/978-3-319-32703-7_128; and in: An, Junmo, Nicholas von Sternberg, Karen Chin, Dipan J. Shah, Andrew G. Webb, and Nikolaos V. Tsekos. "Localization and tracking with RF coils that are optically detuned by the control of an MR compatible manipulator." In Proc. Intl. Soc. Mag. Reson. Med, vol. 22, p. 2326. 2014; and in: An, Junmo, Andrew Webb, Ioannis Seimenis, Eftychios Christoforou, and Nikolaos V. Tsekos. "Tracking of MR compatible interventional robots by controlling the MRI visibility of optically detunable MR markers." Physica Medica: European Journal of Medical Physics 30 (2014): e51. DOI: 10.1016/j.ejmp.2014.07.155; and in: An, Junmo, Mahmut Unan, Karen Chin, Dipan J. Shah, Andrew G. Webb, Ioannis Seimenis, and Nikolaos V. Tsekos. "3D Reconstruction of Tubular Structures from Three Orthogonal MRI Projections." In XIV Mediterranean Conference on Medical and Biological Engineering and Computing 2016, pp. 326-331. Springer, Cham, 2016; and in: An, Junmo, Andrew Webb, Ioannis Seimenis, Eftychios Christoforou, and Nikolaos V. Tsekos. "MR compatible endoscope for assessing the spatial distribution of co-registered optical and 1H signals." Physica Medica: European Journal of Medical Physics 30 (2014): e39. DOI: 10.1016/j.ejmp.2014.07.120; and in: An, Junmo, Ahmet E. Sonmez, Mahmut Unan, Robert D. Darrow, Ileana Hancu, R. Jason Stafford, Andrew G. Webb, and Nikolaos V. Tsekos. "Manipulator-mounted optical/NMR dual-modality probe for multimodality scanning in MR guided and robot-assisted interventions."

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http://hdl.handle.net/10657/3273

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