Browsing by Author "Swoboda, Jonathan G."
Now showing 1 - 1 of 1
- Results Per Page
- Sort Options
Item Development of improved inhibitors of wall teichoic acid biosynthesis with potent activity against Staphylococcus aureus(Bioorganic and Medicinal Chemistry Letters, 2011-03) Lee, Kyungae; Campbell, Jennifer; Swoboda, Jonathan G.; Cuny, Gregory D.; Walker, SuzanneA small molecule (1835F03) that inhibits Staphylococcus aureus wall teichoic acid biosynthesis, a proposed antibiotic target, has been discovered. Rapid, parallel, solution-phase synthesis was employed to generate a focused library of analogs, providing detailed information about structure–activity relationships and leading to the identification of targocil, a potent antibiotic.