Browsing by Author "Sachanandani, Suresh B."
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Item Synthesis of organophosphorous hydrazides and structurally related compounds(1974) Sachanandani, Suresh B.; Cates, L. A.; Driever, Carl W.; Zlatkis, AlbertQuarternary ammonium compounds generally possess anticholinergic activity. An example of this is the ganglionic Mocking agent, hexa-methonium chloride: (CHg)g-N+-(CH[subscript 2])[subscript 6]-N+-(CH[subscript 3])[subscript 3] 2 Cl -. Procarbzine, which has the structure: (p-CH[subscript 2]-NH-NH-CH[subscript 3]PhCONHCH(CH[subscript 3])[subscript 2] is an antineoplastic agent. The hydrazine moiety in this compound appears with frequency in antineoplastic agents. Keeping these structure-activity relationships in mind, the following compounds were synthesized for biological evaluation.[...]