Browsing by Author "Nguyen, David"
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Item CaliALI(2017-10-12) Hong, Mitchell; Nguyen, David; Nguyen, Paul; Prajapati, Parth; Sanford, MichaelUC Berkley’s study found 60% of respondents reported upper extremity or neck pain attributed to computer use. The team’s goal is to create plug-and-play hardware designed to articulate automatically to a user to optimize and increase viewing ergonomics. Uses facial tracking & motors for movement. Designed to increase ergonomics for daily tasks. The first of its kind to introduce a dynamic mount enhancing user comfort and visibility.Item How has the COVID-19 pandemic affected traditionally disadvantaged students taking the ACT in a low-income Houston high school?(2022-04-14) Foreman, Shane; Nguyen, David; Patel, Diya; Zaman, SamihaDuring the pandemic, high school students from underserved communities in Houston faced greater challenges in accessing college preparatory resources than ever before. ImpACT (Invested, Motivated, and Prepared for the ACT) is a service-learning project in the Bonner Leaders Program within The Honors College at the University of Houston. Its mission is to fight poverty, bridging the academic achievement gap with personalized college mentorship for underserved high school students. Undergraduate mentors guide students through test-taking strategies for each ACT subject and assist them in navigating their journey to higher education by providing further resources. By working with community partners, undergraduate student mentors, and high school students, ImpACT strives to help students achieve a 2-point ACT score increase (COVID-adjusted), an increase in academic test-taking confidence, and a stronger understanding of post-secondary options. During the fall 2021 semester, ImpACT conducted an ACT and college prep program consisting of seven virtual sessions focused on ACT strategies and practice questions. Seven KIPP Sunnyside seniors participated in the program, which ran from September to October 2021. Students’ ACT scores were collected from ACT exams administered in April 2021, a couple of months before the program, and October 2021, directly after the program. Analysis on student data showed that after participating in the program, the students’ ACT scores remained consistent to national ACT score performance trends, indicating the need to continue providing more support and resources to underserved students at low-income Houston high schools.Item Study of Passive and Active Magnetic Levitation Bearings for Implementation in Pediatric Left Ventricle Assistant Device(2023-04-13) Nguyen, DavidKinase Probes (KP) are molecules that can modify the activities of proteins selectively. The use of a KP is significant because it allows researchers to see how the KP interacts with the target protein mechanistically in vitro or in vivo. The electrophile is a valuable component of a KP. The electrophile must be capable of forming a covalent bond with the catalytic lysine of a PK. When the catalytic lysine is targeted and the kinase site is activated, the PK's stabilization becomes dependent on it. The electrophile must be chosen carefully when targeting the catalytic lysine. A component of KP, a compound we are developing, binds to numerous kinases. However, known electrophiles, such as sulfonyl fluorides probes, are thought to be overly reactive. We don't want to have a KP that only reacts with tyrosine-protein kinase. The question of whether the electrophile only covalently binds to the lysine on Cyclin-dependent kinase 5 (CDK5) or whether the electrophile can also form a bond with other kinases arises during the development of this electrophile that is expected to target the catalytic lysine. In addition to this, fluorine screening concerning different mono-, di-, and tri-fluorine substitution reactions are what we are performing as well. Because of the high sensitivity of the 19F nuclei found in nuclear magnetic resonance (NMR) measurements, many fluorinated molecules are used in pharmaceuticals. According to many studies, about a third of new approved drugs contain fluorine atoms or fluoroalkyl groups. Additionally, fluorine substitution reactions affect kinetic activity. This project was completed with contributions from Victor Tesesco and Yaxin Wang from the Texas Heart Institute.